辅酶Q10联合还原性谷胱甘肽对肿瘤常规放射治疗患者的保护作用(1)
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[摘要] 目的：探讨辅酶Q10联合还原型谷胱甘肽对肿瘤常规放射治疗患者的保护作用。方法：采用随机对照方法，将960例胸部恶性肿瘤放疗患者随机分为三组：A组为实验组，口服辅酶Q10，60 mg/d；同时应用还原型谷胱甘肽钠，1.2 g/d，静脉滴注，每日1次。B、C组为对照组，B组应用还原型谷胱甘肽钠，1.2 g/d，静脉滴注，每日1次；C组为空白对照组。分析并比较三组的白细胞下降、放射性食管炎及放射性肺炎的发生率差异。结果：白细胞下降方面，三组间比较，差异均无统计学意义(均P>0.05)。放射性食管炎方面，B组与A、C组比较，差异均无统计学意义(均P>0.05)；A组与C组比较，差异有统计学意义(P<0.05)。放射性肺炎方面，B组与A、C组比较，差异均无统计学意义(均P>0.05)；A组与C组比较，差异有统计学意义(P<0.05)。结论：辅酶Q10联合还原型谷胱甘肽对肿瘤常规放射治疗患者有保护作用，值得临床推广使用。
[关键词] 辅酶Q10；还原型谷胱甘肽；恶性肿瘤放射治疗
[中图分类号] R730.53[文献标识码]A [文章编号]1673-7210(2010)10(c)-030-02
The protection of coenzyme Q10 combined reduced glutathione for the patients with conventional radiotherapy
CUAN Guoqing, SHI Zhongzhou, LI Chaoyuan, LIU Liping
(Department of Medical Oncology, the Second People′s Hospital of Pingdingshan City, He′nan Province, Pingdingshan 467000, China)
[Abstract] Objective: To discuss the protection of coenzyme Q10 combined reduced glutathione for the patients with conventional radiotherapy. Methods: 960 cases of breast cancer patients receiving radiotherapy were randomly divided into 3 groups according torandom controlled method, group A was the experiment group, oral administration of coenzyme Q10, 60 mg/d; at the same time take reduced glutathione sodium, 1.2 g/d, intravenous infusion, once a day. Group B and group C for the control groups, group B take reduced glutathione sodium, 1.2 g/d, intravenous infusion, once a day; group C was the blank control group. The incidence rates of leukopenia, radiation esophagitis and radiation pneumonitis in three groups were compared. Results: There was no significant difference in three groups on the leucopenia (all P>0.05). There was no significant difference in group B compared with group A, C(all P>0.05), and there was a significant difference between group A and C (P<0.05) on the radiation esophagitis and radiation pneumonitis respectively. Conclusion: Coenzyme Q10 combined reduced glutathione sodium has a protective effect for the cancer patients treated with conventional radiation, so it is worthy of clinical use ......
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