莫沙必利联合思连康治疗功能性消化不良的疗效观察(1)
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[摘要] 目的：观察莫沙必利联合思连康治疗功能性消化不良的临床疗效。方法：选择2006年1月～2009年4月功能性消化不良患者152例，随机分为治疗组和对照组。治疗组76例采用枸橼酸莫沙必利分散片5 mg，每日3次； 思连康1.5 g，餐后用50°C以下温水或牛奶送服，3次/d。对照组采用多潘立酮片10 mg，每日3次口服。结果：治疗组显效率为59.2%、总有效率为88.2%，对照组显效率为25.0%、总有效率为63.2%，两组间有非常显著性差异(P<0.01)。治疗结束后1年，治疗组复发率为7.5%，对照组复发率为33.3%，两组复发率比较，有非常显著性差异(P<0.01)。结论：莫沙必利联合思连康治疗功能性消化不良的疗效明显，安全可靠。
[关键词] 莫沙必利；思连康；功能性消化不良
[中图分类号] R574.4[文献标识码]B [文章编号]1673-7210(2010)10(c)-066-02
Efficacy observation of Mosapride combined with Siliankang in the treatment of functional dyspepsia
CHENG Yanjie
(General Hospital of Liaoyuan Mining Group, Jilin Province, Liaoyuan 136200, China)
[Abstract] Objective: To observe the clinical effect of Mosapride combined with Siliankang in the treatment of functional dyspepsia. Methods: 152 patients of functional indigestion were selected and randomly divided intotreatment group and control group. 76 cases in treatment group used Mosapride Citrate 5 mg dispersible tablet, 3 times a day; Siliankang 1.5 g with 50 degrees below the water or milk pills after the meal, 3 times a day. 76 cases in control group used Domperidone Tablets 10 mg, 3 times a day. Results: The obvious effective rate of treatment group was 59.2%, the total effective rate was 88.2%, the obvious effective rate of control group was 25.0%, the total effective rate was 63.2%, there was very significant difference between two groups (P<0.01). One year after treatment, the recurrence rate of treatment group was 33.3% and the control group was 7.5%, there was very significant difference between two groups (P<0.01). Conclusion: The curative effect of Mosapride combined with Siliankang in the treatment of unctional dyspepsia is significantly, safe and reliable.
[Key words] Mosapride; Siliankang; Functional dyspepsia
功能性消化不良(functional dyspepsia， FD)是消化内科的常见病，以持续性或反复性上腹部不适、腹胀、嗳气等为临床表现，易反复发作，长期困扰患者，严重影响患者生活质量。因其病因与发病机制至今不明，目前仍缺乏满意的治疗方案。我院应用莫沙必利联合思连康治疗FD患者，取得了满意的疗效，现报道如下：
1 资料与方法
1.1 一般资料
选择2006年1月～2009年4月功能性消化不良患者152例，符合2006年FD罗马Ⅲ诊断标准[1]，病例入选标准：持续或反复发作的上腹正中的疼痛或不适症状 ......
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