CD147与基质金属蛋白酶-3在急性白血病细胞中的表达及其意义(1)
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[摘要] 目的 探讨CD147和基质金属蛋白酶-3(MMP-3)在急性白血病患者细胞中的表达情况及其相关性。 方法 应用流式细胞术检测CD147表达水平，免疫组化染色法检测MMP-3蛋白的表达情况，比较其在初治、复发、完全缓解的急性白血病患者中的表达变化及其相关性。 结果 CD147和MMP-3在白血病初治及复发组中的表达水平显著高于缓解组和对照组(P < 0.05)；初治组中髓外浸润组CD147和MMP-3水平显著高于非髓外浸润组(P < 0.05)；经相关性分析显示，CD147和MMP-3表达呈正相关关系(r = 0.574，P < 0.01)。 结论 CD147和MMP-3在急性白血病细胞中高表达，可能与白血病细胞髓外浸润过程有关。
[关键词] 细胞外基质金属蛋白酶诱导因子；基质金属蛋白酶-3；急性白血病；髓外浸润
[中图分类号] R557 [文献标识码] A [文章编号] 1673-7210(2012)02(a)-0059-03
Expression and significance of CD147 and MMP3 in acute leukemia cells
SHI Yanrong1,2 LIU Yanfang1▲ SUN Hui1 ZHANG Qiutang1 SUN Ling1
1.Department of Hematology, the First Affiliated Hospital of Zhengzhou University, He'nan Province, Zhengzhou 450052, China; 2.General Hospital of Pingdingshan Coal Group Ltd Co, He'nan Province, Pingdingshan 467000, China
[Abstract] Objective To investigate the correlation and expression of CD147 and MMP-3 in acute leukemia cells. Methods The expression of CD147 was detected by flow cytometry and the protein expression of MMP-3 was assessed by immunohistochemistry. The expression level and the correlation of CD147 and MMP-3 in acute leukemia patients with different stage of initial treatment, relapsed and complete remission were compared. Results The expression of CD147 and MMP-3 of initial treatment group and relapsed group were significantly higher than that of complete remission group and control group (P < 0.05). The expression of CD147 and MMP-3 of extra-medullary infiltration group in initial treatment group were significantly higher than that of non- extra-medullary infiltration group (P < 0.05). The correlation analysis showed that the expression of CD147 was positively correlated with the expression of MMP-3 (r = 0.574, P < 0.01). Conclusion The high expression of CD147 and MMP-3 in acute leukemia cells may be related to the extra-medullary infiltration.
[Key words] CD147; MMP-3; Acute leukemia; Extra-medullary infiltration
基质金属蛋白酶(matrix metalloproteinases，MMPs)能降解细胞外基质中的多种蛋白成分，在恶性肿瘤的侵袭和转移中起重要作用。细胞外基质金属蛋白酶诱导因子(extracellularmatrix metalloproteinase inducer ......
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