毛细支气管炎患儿辅助性T淋巴细胞测定(1)
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【摘要】 目的 测定毛细支气管炎患儿急性发作期和恢复期血Th1细胞(Thelper1)和Th2细胞(Thelper2),研究Th1/Th2失衡和毛细支气管炎急性发作的关系,推断T淋巴细胞在毛细支气管炎发生发展过程中的作用。方法 观察组35例毛细支气管炎患儿,分别于治疗前和治疗后应用流式细胞术测定血样本中Th1和Th2数量;对照组11例。结果 观察组治疗前Th2明显升高,Th1/Th2比值明显降低,与对照组比较有统计学差异(P<0.01);观察组治疗后Th2有所下降,Th1/Th2比值有所增加,与治疗前比较有统计学差异(P<0.01),但与对照组比较差异仍有统计学意义(P<0.01)。结论Th2优势应答可能在毛细支气管炎急性发作过程中起重要作用。
【关键词】毛细支气管炎;Th1/Th2失衡;流式细胞术
Clinical studies on disturbance of T helper cell in exacerbatin stage of bronchiolitis
CHANG Shaohong,ZHANG Weixing,LUAN Bin.
【Abstract】 Objective To explore the change of Th1 and Th2 in the stage of exacerbation and recovery in children with bronchiolitis.Methods Thirtyfive patients with bronchiolitis were entered in the study,and Th1 and Th2 were determined by flow cytometer in the acute stage and recovery.Results Compared with control group,Th2 cells of bronchiolitis patients in the acute stage was significantly increased and Th1/Th2 ratio was significantly decreased(P<0 ......
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