急性心肌梗死患者血浆脂联素和超敏C反应蛋白的临床分析(1)
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【摘要】目的探讨急性心肌梗死(AMI)患者血浆脂联素(APN)和超敏C反应蛋白(hsCRP)的变化及其临床意义。方法选择AMI患者50例,入院后均行超声心动图检查评价室壁运动和心功能,并设对照组(30例)进行比较。采用ILISA法测定APN,免疫散射比浊法检测hsCRP水平。结果AMI患者APN水平显著低于正常心功能对照组(P<0.01),hsCRP水平显著高于正常心功能对照组(P<0.01)。AMI患者APN、hsCRP水平与左心室射血分数(LVEF)呈负相关(r=0.549,P<0.01)。结论血浆APN、hsCRP水平与预后显著相关,对AMI的辅助诊断、疗效观察及预后判断具有重要价值。
【关键词】
急性心肌梗死;脂联素;超敏C反应蛋白
Clinical analysis of plasma adiponectin and hsCRP in patients with acute myocardial infarction
MA Xiangwen,WANG Xian,LI Jian.Department of Endocrinology,Women and Children Hospital,Weifang,Shangdong Province 261011,China
【Abstract】ObjectiveTo explore the variation and significance of plasma adiponectin(APN)and high
sensitivety Creactive protein(hsCRP)in patients with acute myocardial infarction(AMI).MethodsThe cases were divided into two groups:AMI group(including 50 AMI patients)and control group(including 30 normal individuals).Plasma concentration of APN was measured by ILISA and hsCRP was measured by immue nephelonretry.ResultsThe concentration of APN in patients with AMI were significantly lower than those in the control group(P<0.01),hsCRP were significantly higher than those in the control group(P<0.01).The concentration of APN and hsCRP in AMI patients had a parallel rationship with LVEDD(r=0.549,P<0,01).ConclusionPlasma APN and hsCRP levels are of great value to the diagnosis,treatment and prognosis of AMI.
【Key words】
Acute myocardial infarction; Adiponectin; High sensitivity Creactive protein
脂肪组织是功能活跃的内分泌器官,可表达和分泌多种参与胰岛素抵抗发生的脂肪细胞因子如肿瘤坏死因子α(TNFα)、抵抗素、瘦素、脂联素等[1]。脂联素(APN)是脂肪细胞分泌的众多激素中的一种。研究表明[2],APN具有调节糖脂代谢、抗IR、抗炎及抗动脉硬化(AS)等功能,在减少心血管疾病的多种危险因素方面发挥着重要的作用。CRP被认为是动脉粥样硬化性血栓形成疾病的介导和标志物[4,5]。本文检测了50例AMI患者和30例对照组的APN和hsCRPde水平,并评估其对AMI的危险分层及判断预后的价值。
1对象与方法
1.1对象选择2006年7月至2008年7月在我院住院的AMI患者50例,其中男34例,女16例,年龄45岁~81岁,平均(57.31±5.23)岁,均符合WHO关于AMI的诊断标准:典型的胸痛持续时间>30 min;ST段上抬>0.2 mv;血清心肌酶谱升高大于正常2倍以上。对照组30例,男21例,女9例,年龄34~74岁,平均年龄54.42±6.42岁,均为健康体检者。经病史、体检和辅助检查,排除心、脑、肾和糖尿病等疾患,未服用任何药物。
1.2方法APN测定用酶联免疫吸附试验(ELISA法),试剂盒由美国Bionewtrans Pharmaciutical Biotechnology Co,Ltd生产(大连泛邦化工技术开发有限公司提供),试剂盒检测线形范围为0.75~30 mg/L,敏感度为0 ......
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