Syndecan-1分子表达水平与子宫内膜增生症进展及预后的关系(1)
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【摘要】 目的 探讨Syndecan-1分子表达水平与子宫内膜增生症进展与预后的关系。方法 采用免疫组织化学染色技术,检测15例单纯性子宫内膜增生(SH)、15例复杂性子宫内膜增生(CH)、15例非典型增生(AH)、24例子宫内膜癌(EC)组织中Syndecan-1分子的表达,与8例正常子宫内膜(NE)组织中的Syndecan-1表达水平进行比较分析。结果 Syndecan-1在NE、SH、CH、AH、EC中的表达平均分值分别为0.50,0.53,1.27,1.67,1.88。Syndecan-1在CH和AH中的表达显著高于SH(P<0.001),CH、AH、EC中Syndecan-1的表达明显强于NE(P=0.041,P=0.006,P=0.02),而NE中Syndecan-1的表达与SH的比较无差异(P>0.50)。结论 Syndecan-1分子表达增高可能促进子宫内膜的恶性转化,检测Syndecan-1分子表达水平可帮助评估子宫内膜增生症预后。
【关键词】 Syndecan-1;子宫内膜增生症;表达;预后
Relationships Between The Expression of Syndecan-1 and Endometrial Hyperplasia Progression and Prognosis
TAN Yi-jun,GAO Wei-fei.Department of Obstetrics and Gynaecology of Loudi City Traditional Chinese Medical Hospital,LoudiHunan,Loudi 417000,China
【Abstract】 Objective To explore the relationships between the expression of syndecan-1 and endometrial hyperplasia progression and prognosis.Methods With immunohistochemical staining of syndecan-1,we analyzed specimens from patients with normal endometrium (NE,N=8) as controls,and those of simple hyperplasia (SH,N=15),complex hyperplasia without atypia (CH,N=15),atypical hyperplasia (AH,N=15),and endometrial cancer (EC,N=24).Results The mean scores of expression based on the frequency of syndecan-1 staining were 0.50,0.53,1.27,1.67 and 1.88 for NE,SH,CH,AH and EC,respectively (P<0.001).Syndecan-1 expression was significantly greaterin CH (P<0.001) or AH (P<0.001) than in SH.Syndecan-1 is more frequently expressed in CH (P=0.041),AH (P=0.006),or EC (P=0.02) than in NE.Syndecan-1expression did not differ significantly between NE and SH (P>0.50).Conclusion Up-regulated expression of syndecan-1 may promote m alignant transformation of the endometrium and the immunohistochemical study of syndecan-1 expression make for evaluation of prognosis of endometrial hyperplasia.
【Key words】Syndecan-1; Endometrial hyperplasia; Expression; Prognosis
子宫内膜癌(endometrial cancer,EC)是女性生殖道最常见的肿瘤之一,其发病率和死亡率有逐年上升的趋势。近年研究表明[1],Syndecan-1作为肿瘤微环境的重要调节者,在肿瘤细胞分化、增殖、侵袭转移、血管生成等过程中起重要作用 ......
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