硫辛酸联合恩再适治疗化疗药物致周围神经病变的疗效分析(1)
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【摘要】 目的 探讨a-硫辛酸联合中痘疫苗致炎兔皮提取物(恩再适)治疗化疗药物致周围神经病变的临床疗效。方法 2008年1月至2010年1月诊治的246例化疗药物致周围神经病变患者,随机分为治疗组126例;对照组120例;治疗组采用a-硫辛酸联合恩再适治疗,对照组采用甲钴胺注射液和维生素B12治疗;观察两组临床疗效。结果 治疗组总有效120例,总有效率95.23%,对照组总有效率99例,总有效率82.5%;两组总有效率比较,P<0.05有显著差异性。结论 a-硫辛酸联合恩再适治疗化疗药物致周围神经病变能够明显的增加感觉神经、运动神经传导速度,改善临床症状。a-硫辛酸联合恩再适治疗化疗药物致周围神经病变临床疗效确切,临床效果具有协同作用。在治疗期间无严重的不良反应,具有高度的安全性。
【关键词】 a-硫辛酸;恩再适;化疗药物致周围神经病变;疗效分析
Alpha lipoic acid combined analgecine on treatrment of chemotherapy in duced peripheral neuropathy
YU Cai-ling.Internal secretion branch.The First people’s hospital of Shangqiu,Henan,Shangqiu 467100,China
【Abstract】 Objective To study a-lipoic acid and then appropriate treatment of co-ex chemotherapy induced peripheral neuropathy clinical efficacy. Methods From January 2008 to 2010 in January 246 patients treated in chemotherapy induced peripheral neuropathy were randomly divided into treatment group 126 cases; the control group of 120 cases; treatment group was a-lipoic acid treatment combined grace and then apply the control group were Methylcobalamin Vitamin B12 Injection and treatment; clinical efficacy. Results The total effective of 120 cases, total effective rate 95.23%, the efficiency of the control group was 99 cases, 82.5%; group total effective rate was P<0.05 significant difference. Conclusion A-lipoic acid and then appropriate treatment of co-ex peripheral neuropathy caused by chemotherapy can significantly increase the sensory nerve, motor nerve conduction velocity, improve clinical symptoms. a-lipoic acid and then appropriate treatment of co-ex chemotherapy induced peripheral neuropathy is effective, the clinical effect is synergistic effect. During treatment,there was no serious adverse reactions, but with high security.
【Key words】 Alpha-lipoic acid;Analgecine;Chemotherapy induced peripheral neuropathy; Effect Analysis
DOI:10.3760/cma.j.issn 1673-8799.2010.11.15
作者单位:467100河南省商丘市第一人民医院
随着生存年龄的增加,肿瘤患者逐渐增加,化疗是目前治疗恶性肿瘤的主要方法之一,在抗肿瘤化疗药物的不良反应中,由化疗药物所致的周围神经病变(chemotherapy-induced peripheral neuropa·thy,CIPN)是常见的副作用之一,临床表现为感觉运动多发性神经病,四肢对称性手套、袜套样深感觉、浅感觉障碍伴四肢远端肌力减退,跟腱反射减退或消失,重者出现肌萎缩[1] ......
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