金水宝胶囊对慢性肾脏病患者血清胱抑素C与超敏C反应蛋白的影响(1)
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【摘要】 目的 观察金水宝胶囊对慢性肾脏病(CKD)患者血清胱抑素C(Cystatin C)与超敏C反应蛋白(hsCRP)的影响。方法 34例明确诊断CKD患者,随机分为对照组(17例)和治疗组(17例),同时选择17名健康成人作为正常对照组,在基础治疗上加用金水宝胶囊3次/d,6粒/次口服,治疗前、后8周分别检测Cystatin C、hsCRP、Scr、BUN。结果 CKD患者Cystatin C、hsCRP、Scr较正常对照组明显增高(P<0.05),常规治疗8周后其Cystatin C、hsCRP、Scr有所降低,但差异无统计学意义(P>0.05),而加用金水宝胶囊治疗后其Cystatin C、hsCRP、Scr明显降低(P<0.05);Cystatin C与hsCRP呈正相关,Cystatin C与GFR呈负相关。结论 金水宝胶囊可改善早期CKD患者的肾功能和炎症状态,有利于延缓CKD的进展。
【关键词】 金水宝胶囊;慢性肾脏病;胱抑素C;超敏C反应蛋白
Influence of jinshuibao capsule on serum cystatin C and high sensitive Creactive protein in chronic kidney disease patients
MA Xichen, TAN Yuli, GU haidong
.Department of Nephrology, the Affiliated Rizhao Hospital of Jining Medical College, Rizhao 276800,China
【Abstract】 Objective To observe the influence of jinshuibao capsule on serum cystatin C and high sensitive Creactive(hsCRP)protein in chronic kidney disease patients(CKD).Methods Thirtyfour cases CKD patients were randomly divided into two groups:control group(17 cases)and treatment group(treatment with jinshuibao capsules, 17 cases). Meanwhile, 17 healthy adults were taken as the normal control. The blood concentrations of cystatin C,hsCRP,Scr and BUN were determined. Results The level of cystatin C,hsCRP,Scr in all CKD patients were significantly higher than those in the normal control(P<0.05), the level of cystatin C,hsCRP,Scr decreased after 8 weeks of conventional treatment(P>0.05), while those significantly decreased addition of jinshuibao capsule treatment(P<0.05); Cystatin C and hsCRP were positively correlated,but Cystatin C was negatively correlated with GFR. Conclusion The renal function and inflammation can be alleviated by jinshuibao capsule in early CKD patients, which could be slowed the progression of CKD.
【Key words】 Jinshuibao capsule; Chronic kidney disease; Cystatin C; CRP
CKD的防治已经成为世界各国所面临的重要公共卫生问题,早期发现CKD并采用适当的措施减慢GFR下降率,有利于延缓CKD的进展。研究表明Cystatin C与GFR有良好的相关性,因此有望成为替代Scr、Ccr的一种可反映GFR的理想标志物。大量研究证实CKD患者存在炎症因子的轻微而持续的活化[1],C反应蛋白(CRP)是急性时相蛋白,用超敏的方法测出较低浓度的CRP为hsCRP,是全身炎症的非特异性标志物。
中医学认为冬虫夏草具有“补益肺肾、秘精益气”之功效,临床上可用于保护肾功能,延缓肾衰进展。金水宝胶囊为发酵虫草菌粉 ......
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