人胎盘组织液抗炎药效学研究
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[摘要] 目的 研究人胎盘组织液的主要药效作用。方法 建立二甲苯所致小鼠耳肿胀及大鼠棉球肉芽肿的药理模型,观察人胎盘组织液对炎症模型动物的抗炎作用。结果 与模型对照组相比,连续7d肌肉注射0.1mL/kg剂量的人胎盘组织液对二甲苯所致小鼠耳肿胀起到明显抑制作用,且差异显著(P<0.01);连续6d肌肉注射0.1mL/kg剂量的人胎盘组织液对大鼠棉球肉芽组织增生起到明显抑制作用,且差异显著(P<0.01)。结论 人胎盘组织液具有明显的抗炎作用。
[关键词] 人胎盘组织液; 抗炎; 耳肿胀; 肉芽肿
[中图分类号] R927.1 [文献标识码] A [文章编号] 1673-9701(2010)15-07-02
Anti-inflammatory Effect of Human Placenta Tissue Fluid:Pharmacodynamics Study
JING Jinzhu1 YUAN Yunhui1SUN Zhipo1 ZHU Zhongning2
1.Handan Kangye Pharmaceutical Co.Ltd.,Handan 056000,China;2.The Center for New Drug Safety Evaluation and Research of Hebei Medical University,Shijiazhuang 050017,China
[Abstract] ObjectiveTo investigate the main therapy effects of human placenta tissue fluid(HPTF). MethodsThe inflammatory models were established by mouse auricular swelling induced by xylene and rat granulation hyperplasia induced by cotton ball,and the effects of HPTF on diminishing inflammation in animal models were observed ......
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