血浆M-CSF和CA15-3在乳腺癌诊断中的临床意义
【摘要】目的:探讨血浆M-CSF及CA15-3在乳腺癌中的诊断价值。方法:分析80名乳腺癌病人,17名良性乳腺病人及30名健康受试者血浆M-CSF和CA15-3。M-CSF和CA15-3采用定量酶联免疫吸附实验(ELISA)检测。结果:乳腺癌病人血浆M-CSF和CA15-3水平与乳腺良性肿瘤组、健康受试者组均有明显统计学差异。M-CSF和CA15-3的诊断特异性为95%。M-CSF的诊断敏感性(59%)阳性预测价值(97%)和阴性预测价值(41%)均高于CA15-3(48.8%,95%和40.1%),两者联用可使其敏感性增加到70%。
【关键词】乳腺癌 CA15-3 M-CSF 肿瘤标志物
Clinical significance of plasma M-CSF and CA15-3 in patients with breast cancer
Yu HongboWu BoyuLiuying
【Abstract】Objective:To explore the diagnostic value of plasm M-CSF and CA153 in patients with breast cancer.Methcds:M-CSF and CA15-3 were measured in 80 patients with breast cancer,17 patients with benign breast tumor and in 30 healthy subjeets.M-CSF and CA15-3 were determined using enzyme-linked immunosorbent assay(ELISA).Results:There were statistically significant differences in the levels of circulating M-CSF and CA 15-3 in the breast cancer patients comparing to the group with benign breast tumor and to the control group.The M-CSF and CA 15-3 diagnostic specificities were 95%.The diagnostic sensitivity(59%) ......
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