【摘要】目的 观察依沙吖啶羊膜腔内注射的基础上联合应用米索前列醇在18~27周中期妊娠引产的应用效果。方法 对来我院自愿要求终止妊娠的孕妇218例，随机分为观察组和对照组各109例。对照组采用传统方法羊膜腔内注射依沙吖啶100 mg。观察组在同法依沙吖啶注射后第2天上午8时予以米索200μg塞阴道。结果 应用依沙吖啶联合米索前列醇在18~27周中期妊娠引产有很好的引产效果，总引产率为100%。尤其在完全流产方面显著高于单用依沙吖啶。在用药至分娩时间和总产程时间方面也显著短于单用依沙吖啶的患者，同时联合用药可以减少产后出血量，也避免宫颈裂伤的发生；联合用药并无严重不良反应发生。结论 依沙吖啶联合应用米索前列醇在18~27周中期妊娠引产具有引产成功率高、产程短、软产道损伤小、清宫率低等优点。所以采用联合用药在中期妊娠引产中值得推广。

    【关键词】依沙吖啶;米索前列醇;中期妊娠;引产

    Clinical Observation of Misoprostol in Combination with Rivanol on Induction of Labor in Mid-pregnancy.DONG Yong-mei,WANG Deng-qiong,WU lin.(The 5th People's Hospital,Si chuan Chengdu 611130,China.)

    【Abstract】Objective To examine the validity and safety of the treatment for induction of labor in mid-pregnancy(18-27 weeks) using misoprostol in combination with fivano1.Methods 218 pregnant women in need of induction of labor were divided into an observation group(109)and a control group(109) randomly. After 100mg rivanol was injected into the amniotic cavity in the observation group ......