摘要 目的：检测强直性脊柱炎(AS)患者的外周血和关节滑液中肿瘤坏死因子-α( TNF-α)水平,并分析TNF-α在关节炎症发生过程中的病理作用。方法：收集90例AS患者和40例健康体检者外周血清和膝关节滑液标本,采用双抗体夹心酶免疫吸附法(ELISA)分析TNF-α水平。结果：AS患者外周血和膝关节滑液中TNF-α水平比健康体检者明显升高(p 0.05). Conclusion：TNF-αis significantly increased in the SF and sera of AS patients. TNF-αmay play an important role in the development of synovial inflammation.

    Key words Ankylosing spondylitis；Peripheral blood；Synovial fluid；TNF-α

    强直性脊柱炎(ankylosing spondylitis,AS) 是一种以中轴关节慢性炎症为主的慢性进展性风湿性疾病 ......