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生长激素缺乏症儿童重组人生长激素替代治疗前后骨代谢指标的变化
http://www.100md.com 2008年6月1日 《医学发展》 2008年第6期
     摘 要目的:研究生长激素缺乏症(GHD)儿童用生长激素治疗前后的骨代谢指标的改变。方法:测定32例生长激素缺乏症(GHD)儿童应用生长激素治疗前、治疗3个月、治疗6个月和35例年龄、性别匹配的正常健康儿童的血清骨钙素(OC)、I型胶原交联羧基末端肽(ICTP)比较各组差异。结果:GHD治疗前组血清OC、ICTP均显著低于正常对照组(P<0.05); GH治疗3月后OC和ICTP均显著高于基线值(P<0.05);GH治疗6月后, OC不再增高,而ICTP随治疗时间延长逐步增高。结论:GHD儿童体内骨转换水平明显降低;GH替代治疗半年后,骨形成和骨吸收指标明显增高。rhGH替代治疗对维持GHD儿童体内正常骨代谢平衡起着重要作用。

    关键词生长激素缺乏症;重组人生长激素;骨钙素;I型胶原交联羧基末端肽

    AbstractObjective:The changes of bone turnover markers in children with growth hormone deficiency (GHD)before and after recombinant human growth hormone (rhGH) replacement therapy. Methords:Serum osteocalcin(OC)and type I collagen cross-linked C-terminal telopeptide(ICTP) in 32 GHD children before and after 3 months and 6 months of rhGH therapy,and compared to 35 age- and sex-matched healthy controls. Results:Compared with the control, baseline serum levels of OC and ICTP in GHD group were significantly decreased(P<0.05), and increased significantly after rhGH replacement therapy for 3 months(P<0.05).After rhGH replacement therapy for 6 months ,ICTP were increasing with the prolonged rhGH replacement therapy,but OC were not increasing.Conclusion:Compared with the control,the level of bone turnover markers are lower significantly in GHD children.But thay can be significantly inproved after rhGH replacement trentment for 6 months. RhGH replacement trentment have important function to maintain the normal balace of bone turnover. ......

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