蛋白激酶B与心肌保护(2)
3 展望
随着PKB/Akt研究的深入，它参与细胞内多种信号途径并调控多种细胞过程的事实已经被证明，在心脏疾病方面如心肌缺血再灌注、心力衰竭等方面必将有潜在的广阔的应用前景。
参考文献
[1] George M N，Denisa M，Petras J，et al.Akt inhibitors in cancer treatment：The long journey from drug discovery to clinical use[J].Int J Oncol，2016，48(03)： 869885.
[2] Yu H，Littlewood T，Bennett M.Akt isoforms in vascular disease[J].Vascul Pharmacol，2015，71：5764.
[3] Chen K，Li G，Geng F，et al.Berberine reduces ischemia/reperfusioninduced myocardial apoptosis via activating AMPK and PI3KAkt signaling in diabetic rats[J].Apoptosis，2014，19：946957.
[4] Tong Y，Li F，Lu Y，et al.Rapamycinsensitive mTORC1 signaling is involved in physiological primordial follicle activation in mouse ovary[J].Mol Reprod Dev，2013，80(12)：101834.
[5] Mocanu M M，Bell R M，Yellon D M.P13 kinase and not p42/p44 appears to be implicated in the protection conferred by ischemic preconditioning[J].Mol Cell Cardiol，2011，34：661668.
[6] Andrew Tsang，Derek J Hausenloy， Derek M Yellon，et al.Postconditioning： A Form of "Modified Reperfusion" Protects the Myocardium by Activating the Phosphatidylinositol 3KinaseAkt Pathway[J].Circulation Research，2012，95：230232.
[7] Zhang M，Wang C，Hu J，et al.Notch3/Akt signaling contributes to OSMinduced protection against cardiac ischemia/reperfusion injury[J].Apoptosis，2015，20(09)：115063.
[8] Xie Q，Sun Z，Chen M，et al.IL8 upregulates proliferative angiogenesis in ischemic myocardium in rabbits through phosphorylation ofAkt/GSK3β(ser9) dependent pathways[J].Int J Clin Exp Med，2015，08(08)：12498508.
[9] Wu Y，Wang B X，Guo Y Y，et al.The effect of relgulation of PPARα on cardiac hypertrophy and the relationship between the effect of PPARα with PI3K/Akt/mTOR pathwa[J].Zhongguo Ying Yong Sheng Li Xue Za Zhi，2015，31(03)：2848.
[10] Kobayashi S，Nakamura T Y，Wakabayashi S.Calcineurin B homologous protein 3 negatively regulates cardiomyocyte hypertrophy via inhibition of glycogen synthase kinase 3 phosphorylation[J].J Mol Cell Cardiol，2015，84：13342.
[11] Oyarzún A P，Westermeier F，Pennanen C，et al.FK866 compromises mitochondrial metabolism and adaptive stress responses in cultured cardiomyocytes[J].Biochem Pharmacol，2015，98(01)：92101., 百拇医药(曹洁玮安占军刘彬)
随着PKB/Akt研究的深入，它参与细胞内多种信号途径并调控多种细胞过程的事实已经被证明，在心脏疾病方面如心肌缺血再灌注、心力衰竭等方面必将有潜在的广阔的应用前景。
参考文献
[1] George M N，Denisa M，Petras J，et al.Akt inhibitors in cancer treatment：The long journey from drug discovery to clinical use[J].Int J Oncol，2016，48(03)： 869885.
[2] Yu H，Littlewood T，Bennett M.Akt isoforms in vascular disease[J].Vascul Pharmacol，2015，71：5764.
[3] Chen K，Li G，Geng F，et al.Berberine reduces ischemia/reperfusioninduced myocardial apoptosis via activating AMPK and PI3KAkt signaling in diabetic rats[J].Apoptosis，2014，19：946957.
[4] Tong Y，Li F，Lu Y，et al.Rapamycinsensitive mTORC1 signaling is involved in physiological primordial follicle activation in mouse ovary[J].Mol Reprod Dev，2013，80(12)：101834.
[5] Mocanu M M，Bell R M，Yellon D M.P13 kinase and not p42/p44 appears to be implicated in the protection conferred by ischemic preconditioning[J].Mol Cell Cardiol，2011，34：661668.
[6] Andrew Tsang，Derek J Hausenloy， Derek M Yellon，et al.Postconditioning： A Form of "Modified Reperfusion" Protects the Myocardium by Activating the Phosphatidylinositol 3KinaseAkt Pathway[J].Circulation Research，2012，95：230232.
[7] Zhang M，Wang C，Hu J，et al.Notch3/Akt signaling contributes to OSMinduced protection against cardiac ischemia/reperfusion injury[J].Apoptosis，2015，20(09)：115063.
[8] Xie Q，Sun Z，Chen M，et al.IL8 upregulates proliferative angiogenesis in ischemic myocardium in rabbits through phosphorylation ofAkt/GSK3β(ser9) dependent pathways[J].Int J Clin Exp Med，2015，08(08)：12498508.
[9] Wu Y，Wang B X，Guo Y Y，et al.The effect of relgulation of PPARα on cardiac hypertrophy and the relationship between the effect of PPARα with PI3K/Akt/mTOR pathwa[J].Zhongguo Ying Yong Sheng Li Xue Za Zhi，2015，31(03)：2848.
[10] Kobayashi S，Nakamura T Y，Wakabayashi S.Calcineurin B homologous protein 3 negatively regulates cardiomyocyte hypertrophy via inhibition of glycogen synthase kinase 3 phosphorylation[J].J Mol Cell Cardiol，2015，84：13342.
[11] Oyarzún A P，Westermeier F，Pennanen C，et al.FK866 compromises mitochondrial metabolism and adaptive stress responses in cultured cardiomyocytes[J].Biochem Pharmacol，2015，98(01)：92101., 百拇医药(曹洁玮安占军刘彬)