现在位置：百拇书刊 > 国外期刊 > 临床调查学报 > 2005年.第11期 《临床调查学报》.2005年.第11期  * A novel immunodeficiency associated with hypomorphic RAG1 mutations and CMV infection  * P-glycoprotein deficiency at the blood-brain barrier increases amyloid- deposition in an Alzheimer disease mouse model  * The role of 2 FOXP3 isoforms in the generation of human CD4+ Tregs  * Endocytosis of HIV-1 activates plasmacytoid dendritic cells via Toll-like receptor– viral RNA interactions  * Lewis X component in human milk binds DC-SIGN and inhibits HIV-1 transfer to CD4+ T lymphocytes  * HIV-infected individuals receiving effective antiviral therapy for extended periods of time continually replenish their viral reservoir  * Human skin cells support thymus-independent T cell development  * PPAR inhibits vascular smooth muscle cell proliferation underlying intimal hyperplasia by inducing the tumor suppressor p16INK4a  * Increased glucose tolerance and reduced adiposity in the absence of fasting hypoglycemia in mice with liver-specific Gs deficiency  * Germinal center exclusion of autoreactive B cells is defective in human systemic lupus erythematosus  * Protein phosphatase 2A is a negative regulator of IL-2 production in patients with systemic lupus erythematosus  * Synaptic activity becomes excitotoxic in neurons exposed to elevated levels of platelet-activating factor  * CD36 involvement in orosensory detection of dietary lipids, spontaneous fat preference, and digestive secretions  * Activation of Notch1 signaling is required for -catenin–mediated human primary melanoma progression  * Pemphigus foliaceus IgG causes dissociation of desmoglein 1–containing junctions without blocking desmoglein 1 transinteraction  * Modulation of atherosclerosis in mice by Toll-like receptor 2  * A variant of SCID with specific immune responses and predominance of T cells  * Hypoxia induces a functionally significant and translationally efficient neuronal NO synthase mRNA variant  * Staphylococcus aureus Panton-Valentine leukocidin directly targets mitochondria and induces Bax-independent apoptosis of human neutrophils  * Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects  * NKT cell–dependent leukemia eradication following stem cell mobilization with potent G-CSF analogs  * BLyS and APRIL in rheumatoid arthritis  * Attenuated liver fibrosis in the absence of B cells  * Treatment of murine Th1- and Th2-mediated inflammatory bowel disease with NF-B decoy oligonucleotides  * Cardiac-specific overexpression of AT1 receptor mutant lacking Gq/Gi coupling causes hypertrophy and bradycardia in transgenic mice  * GM-CSF action in the CNS decreases food intake and body weight  * Disease-related phenotypes in a Drosophila model of hereditary spastic paraplegia are ameliorated by treatment with vinblastine  * A cancer-specific transcriptional signature in human neoplasia  * Hemin-activated macrophages home to the pancreas and protect from acute pancreatitis via heme oxygenase-1 induction  * Combretastatin A4 phosphate induces rapid regression of tumor neovessels and growth through interference with vascular endothelial-cadherin  * Infiltration of COX-2–expressing macrophages is a prerequisite for IL-1–induced neovascularization and tumor growth  * New insights into nNOS regulation of vascular homeostasis  * Variable phenotypic expression of mutations in genes of the immune system  * When 7 transmembrane receptors are not G protein–coupled receptors  * All neuropathies great and small  * CD36 may determine our desire for dietary fats  * B cells: no longer bystanders in liver fibrosis