《联合生物学》.2005年.第1期

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• Catalytically inactive human cathepsin D triggers fibroblast invasive growth
• Ultrastructural identification of uncoated caveolin-independent early endocytic vehicles
• Clathrin- and caveolin-1–independent endocytosis : entry of simian virus 40 into cells devoid of caveolae
• Receptor tyrosine phosphatase–dependent cytoskeletal remodeling by the hedgehog-responsive gene MIM/BEG4
• Concentric zones of active RhoA and Cdc42 around single cell wounds
• Molecular mechanisms of invadopodium formation : the role of the N-WASP–Arp2/3 complex pathway and cofilin
• New GABAergic interneurons in the adult neocortex and striatum are generated from different precursors
• The vacuolar kinase Yck3 maintains organelle fragmentation by regulating the HOPS tethering complex
• The molecular mechanisms underlying BiP-mediated gating of the Sec61 translocon of the endoplasmic reticulum
• Chromosome looping in yeast : telomere pairing and coordinated movement reflect anchoring efficiency and territorial organization
• X chromosome choice occurs independently of asynchronous replication timing
• Myosin V attachment to cargo requires the tight association of two functional subdomains
• Viral killer toxins induce caspase-mediated apoptosis in yeast
• A role for myosin VI in postsynaptic structure and glutamate receptor endocytosis
• Gp135/podocalyxin and NHERF-2 participate in the formation of a preapical domain during polarization of MDCK cells
• Effects of Arp2 and Arp3 nucleotide-binding pocket mutations on Arp2/3 complex function
• ARFGAP1 plays a central role in coupling COPI cargo sorting with vesicle formation
• BACE overexpression alters the subcellular processing of APP and inhibits A deposition in vivo
• Generation of nonidentical compartments in vesicular transport systems
• Role of mitochondria in the pheromone- and amiodarone-induced programmed death of yeast
• Actin-myosin–based contraction is responsible for apoptotic nuclear disintegration
• Nuclear transport of single molecules : dwell times at the nuclear pore complex
• Ect2 and MgcRacGAP regulate the activation and function of Cdc42 in mitosis
• Spindle-independent condensation-mediated segregation of yeast ribosomal DNA in late anaphase
• The offloading model for dynein function : differential function of motor subunits
• Muscle expression of a local Igf-1 isoform protects motor neurons in an ALS mouse model
• Cell growth–dependent coordination of lipid signaling and glycosylation is mediated by interactions between Sac1p and Dpm1p
• A multistep, GTP-driven mechanism controlling the dynamic cycling of nucleostemin
• Going in GTP cycles in the nucleolus
• CLASP1 and CLASP2 bind to EB1 and regulate microtubule plus-end dynamics at the cell cortex
• RPTP is essential for NCAM-mediated p59fyn activation and neurite elongation
• The PSD95–nNOS interface : a target for inhibition of excitotoxic p38 stress-activated protein kinase activation and cell death
• Mdm31 and Mdm32 are inner membrane proteins required for maintenance of mitochondrial shape and stability of mitochondrial DNA nucleoids in
• HECT ubiquitin ligases link viral and cellular PPXY motifs to the vacuolar protein-sorting pathway
• Specialized membrane-localized chaperones prevent aggregation of polytopic proteins in the ER
• Identification of cytoplasmic residues of Sec61p involved in ribosome binding and cotranslational translocation
• p107 inhibits G1 to S phase progression by down-regulating expression of the F-box protein Skp2
• Condensed mitotic chromatin is accessible to transcription factors and chromatin structural proteins
• MITF links differentiation with cell cycle arrest in melanocytes by transcriptional activation of INK4A
• Glycogen synthase kinase-3 is an endogenous inhibitor of Snail transcription : implications for the epithelial–mesenchymal transition
• Centrosome fragments and microtubules are transported asymmetrically away from division plane in anaphase
• Hydrogen peroxide as a signal controlling plant programmed cell death
• Regulation of 51 integrin conformation and function by urokinase receptor binding