维生素E对1型糖尿病患者心脏有益
http://www.100md.com
2000年11月15日
NEW YORK (Reuters Health) - Routinely taking a vitamin E supplement may have a beneficial effect on the hearts of people with type 1 diabetes, study findings suggest.
Patients who took moderately high doses of the antioxidant vitamin were less likely to have oxidative changes in LDL (''bad'') cholesterol than patients who took a placebo (inactive) pill, according to a report in the November issue of the American Journal of Clinical Nutrition.
When LDL is oxidized, or modified, it is more likely to deposit in arteries and lead to heart disease. Because type 1 diabetes patients have high blood sugar, they are at greater risk for the oxidation of LDL.
Type 1 diabetes most often occurs in children and young adults and results in life-long dependence on insulin injections for survival. Type 2 diabetes--the more common condition--usually occurs in adulthood and can sometimes be controlled with diet and exercise.
``Life-long supplementation with vitamin E should be considered in patients with type 1 diabetes,'' according to Dr. Wendy Engelen and colleagues from the University of Antwerp in Belgium.
The researchers gave 22 patients 168 milligrams (250 International Units) of vitamin E three times a day for 1 year. Another group of 22 patients took a placebo pill for 6 months, and then the same amount of vitamin E for 6 months. The recommended dietary allowance for vitamin E is 10 milligrams or (15 IU), but the moderately high levels used in the study are likely to be safe, according to the report.
Three months after taking the vitamins, blood samples from patients contained LDL that was less susceptible to oxidation than those from patients not taking the vitamins. The vitamins, however, did not make any other favorable changes, such as lowering blood sugar or modifying cholesterol.
Amounts of vitamin E in the blood rose two to four times 3 months after patients began taking vitamin E, and then remained stable. Vitamin E levels returned to normal 3 months after patients stopped taking supplements.
``All of these observations suggest that to maintain high-normal vitamin E concentrations in both plasma and tissues, uninterrupted supplementation is preferable to short-duration 'cures' with high-dose supplementation or intravenous loading,'' Engelen and colleagues conclude.
SOURCE: American Journal of Clinical Nutrition 2000;72:1142-1149., http://www.100md.com
Patients who took moderately high doses of the antioxidant vitamin were less likely to have oxidative changes in LDL (''bad'') cholesterol than patients who took a placebo (inactive) pill, according to a report in the November issue of the American Journal of Clinical Nutrition.
When LDL is oxidized, or modified, it is more likely to deposit in arteries and lead to heart disease. Because type 1 diabetes patients have high blood sugar, they are at greater risk for the oxidation of LDL.
Type 1 diabetes most often occurs in children and young adults and results in life-long dependence on insulin injections for survival. Type 2 diabetes--the more common condition--usually occurs in adulthood and can sometimes be controlled with diet and exercise.
``Life-long supplementation with vitamin E should be considered in patients with type 1 diabetes,'' according to Dr. Wendy Engelen and colleagues from the University of Antwerp in Belgium.
The researchers gave 22 patients 168 milligrams (250 International Units) of vitamin E three times a day for 1 year. Another group of 22 patients took a placebo pill for 6 months, and then the same amount of vitamin E for 6 months. The recommended dietary allowance for vitamin E is 10 milligrams or (15 IU), but the moderately high levels used in the study are likely to be safe, according to the report.
Three months after taking the vitamins, blood samples from patients contained LDL that was less susceptible to oxidation than those from patients not taking the vitamins. The vitamins, however, did not make any other favorable changes, such as lowering blood sugar or modifying cholesterol.
Amounts of vitamin E in the blood rose two to four times 3 months after patients began taking vitamin E, and then remained stable. Vitamin E levels returned to normal 3 months after patients stopped taking supplements.
``All of these observations suggest that to maintain high-normal vitamin E concentrations in both plasma and tissues, uninterrupted supplementation is preferable to short-duration 'cures' with high-dose supplementation or intravenous loading,'' Engelen and colleagues conclude.
SOURCE: American Journal of Clinical Nutrition 2000;72:1142-1149., http://www.100md.com
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