打嗝有治了
http://www.100md.com
2000年12月28日
NEW YORK (Reuters Health) - Ever experience hiccups so maddening you wanted to scream? According to a pair of Italian physicians, there may now be a relatively simple solution to intractable hiccups.
In the December 28th issue of The New England Journal of Medicine, Drs. Frederico Bilotta and Giovanni Rosa, of the University of Rome La Sapienza, describe the successful treatment of three patients with intense hiccups that would not respond to the usual treatments.
The first patient was a 32-year-old woman with leukemia. Her hiccups had persisted for 2 days. Conventional treatments ''were all ineffective,'' the doctors write.
Then, they tried nefopam, a pain-killer chemically similar to antihistamines. Ten milligrams of the nefopam and the hiccups stopped.
The hiccups recurred 4 hours later and the patient was placed on an intravenous regimen of 10 milligrams nefopam four times per day. She also received ``200 milligrams of carbamazepine orally three times a day without recurrence of the hiccups,'' Bilotta and Rosa explain. Carbamazapine is a drug often used to control seizures.
The next patient was an immunodeficient 25-year-old woman who had a fungal infection of the esophagus. Infusion of nefopam worked for her as well.
The last patient was a 58-year-old man who was undergoing a delicate procedure on a malformed cluster of blood vessels in his brain. His hiccups also responded within one minute to the same 10 milligram dose of nefopam.
``Our experience suggests that patients with severe hiccups that are resistant to (conventional measures), can have a rapid response to intravenous nefopam,'' the doctors conclude.
SOURCE: The New England Journal of Medicine 2000;343:1973-1974., 百拇医药
In the December 28th issue of The New England Journal of Medicine, Drs. Frederico Bilotta and Giovanni Rosa, of the University of Rome La Sapienza, describe the successful treatment of three patients with intense hiccups that would not respond to the usual treatments.
The first patient was a 32-year-old woman with leukemia. Her hiccups had persisted for 2 days. Conventional treatments ''were all ineffective,'' the doctors write.
Then, they tried nefopam, a pain-killer chemically similar to antihistamines. Ten milligrams of the nefopam and the hiccups stopped.
The hiccups recurred 4 hours later and the patient was placed on an intravenous regimen of 10 milligrams nefopam four times per day. She also received ``200 milligrams of carbamazepine orally three times a day without recurrence of the hiccups,'' Bilotta and Rosa explain. Carbamazapine is a drug often used to control seizures.
The next patient was an immunodeficient 25-year-old woman who had a fungal infection of the esophagus. Infusion of nefopam worked for her as well.
The last patient was a 58-year-old man who was undergoing a delicate procedure on a malformed cluster of blood vessels in his brain. His hiccups also responded within one minute to the same 10 milligram dose of nefopam.
``Our experience suggests that patients with severe hiccups that are resistant to (conventional measures), can have a rapid response to intravenous nefopam,'' the doctors conclude.
SOURCE: The New England Journal of Medicine 2000;343:1973-1974., 百拇医药