年轻患者对Hiv药物反应较快
http://www.100md.com
2001年4月12日
NEW YORK (Reuters Health) - The immune systems of younger HIV-infected patients taking potent HIV-suppressing drug 'cocktails' appear to bounce back faster after treatment than those of older patients, researchers report.
According to European investigators, blood counts of CD4+ immune cells rise more quickly in younger versus older patients placed on these multidrug therapies.
``Younger age may favor CD4 cell restoration,'' conclude researchers led by Dr. Jean-Paul Viard of Hopital Necker-Enfants Malades, in Paris.
Writing in the April 15th issue of the Journal of Infectious Diseases, Viard's team compared the 31-month CD4+ counts of nearly 2,000 HIV-positive patients, aged 16 years and older.
All of the patients had similar treatment histories, including the use of protease inhibitor drug 'cocktails' that have been so effective in keeping HIV at bay.
However, the researchers report that the time needed for CD4+ cell counts to reach a relatively safe threshold (over 200 cells per microliter of blood) ``was shorter for patients in the younger age groups'' versus those in older patients.
Viard's group theorizes that the more rapid response of younger patients may be due to a more robust function of the thymus, an organ situated above the heart that produces immune cells--but decreases in size with age.
SOURCE: The Journal of Infectious Diseases 2001;183:1290-1294., 百拇医药
According to European investigators, blood counts of CD4+ immune cells rise more quickly in younger versus older patients placed on these multidrug therapies.
``Younger age may favor CD4 cell restoration,'' conclude researchers led by Dr. Jean-Paul Viard of Hopital Necker-Enfants Malades, in Paris.
Writing in the April 15th issue of the Journal of Infectious Diseases, Viard's team compared the 31-month CD4+ counts of nearly 2,000 HIV-positive patients, aged 16 years and older.
All of the patients had similar treatment histories, including the use of protease inhibitor drug 'cocktails' that have been so effective in keeping HIV at bay.
However, the researchers report that the time needed for CD4+ cell counts to reach a relatively safe threshold (over 200 cells per microliter of blood) ``was shorter for patients in the younger age groups'' versus those in older patients.
Viard's group theorizes that the more rapid response of younger patients may be due to a more robust function of the thymus, an organ situated above the heart that produces immune cells--but decreases in size with age.
SOURCE: The Journal of Infectious Diseases 2001;183:1290-1294., 百拇医药