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强大的“狂暴”音乐可以增强安非他明对大脑的损害(上)
http://www.100md.com 2001年11月6日 好医生
     &nbps;&nbps;&nbps;&nbps;NEW YORK, Nov 02 (Reuters Health) - What do you get when you subject mice to high-decibel dance music and the "party" drug methamphetamine? The answer, according to researchers, is much more brain damage than if the mice were exposed to either the music or the drug alone.

    &nbps;&nbps;&nbps;&nbps;"The take-home message for 'club kids' or 'ravers' is that they should enjoy the party, but avoid using stimulant drugs such as meth," said lead researcher Dr. Jenny Morton of the University of Cambridge in the UK. Her team published the findings in the October issue of NeuroReport.

    &nbps;&nbps;&nbps;&nbps;Experts have long known that a wide variety of party drugs--including methamphetamine and Ecstasy--can do serious short- and long-term damage to brain cells. But how does the loud environment in which these drugs are most often consumed impact on that damage?

    &nbps;&nbps;&nbps;&nbps;In their study, Morton and her colleagues examined the behaviors of groups of 9 or 10 healthy adult mice. Some of the mice were injected with a harmless saline solution, while the others received methamphetamine injections.

    &nbps;&nbps;&nbps;&nbps;The mice were then subjected to one of four aural environments: silence or high decibels of either "white noise," Johann Sebastian Bach or the popular rave group Prodigy. Loudness levels were cranked up to levels found in urban dance clubs.

    &nbps;&nbps;&nbps;&nbps;The result? "Mice exposed to music alone (no meth) were completely unaffected," Morton told Reuters Health. "In fact, within half an hour most of them were asleep."

    &nbps;&nbps;&nbps;&nbps;Mice given meth in the "silent" or "white noise" conditions went through a typical pattern of methamphetamine intoxication, characterized by repetitive movements lasting 60 to 90 minutes, then returned to a more normal state.

    &nbps;&nbps;&nbps;&nbps;"In contrast, mice exposed to meth and loud music rapidly became (intoxicated) and remained so for at least 2 hours," Morton reported. She added that certain erratic, unusual movements, such as "backward walking," occurred only in those mice exposed to both meth and loud music., 百拇医药