轴突导向的新观点
7.9 Schmucker etal.
提出一新观点，指出果蝇轴突导向中确有信号分子受体的作用存在。
人类唐氏综合症细胞粘连分子在果蝇中的同源物是Dacam，它与Dock相互作用，进而得到分离，Dscam是免疫球蛋白超家族中的一员，其结构与许多常见的轴突导向受体相似。Schmucker etal.发现，Dscam在轴突中表达，其突变体会引起导向出现缺陷，而Dscam的基因结构更是让人大吃一惊，Dscam基因具有相当多的剪切方式，形成蛋白千变万化，但都有相同的结构域，如果每种剪切方式都产生蛋白，那么将有38,000种之多，在神经系统尚未发现这种好象免疫抗体类蛋白才会有的现象。
Dscam好象是探测器的接收器，那么谁是派出的探测器呢?Dscam的配体还未确定。它的人类同源物也是轴突导向受体吗?
The peripheral
nervous system (green processes) in a Drosophila embryo. The green
shadow in the background corresponds to the central nervous system. (Photograph courtesy of J. R. Riesgo, Instituto de Neurobiología,UNAM, Mexico).
相关文章：
Original research paper
Schmucker, D. et al. Drosophila Dscam is an axon
guidance receptor exhibiting extraordinary molecular diversity. Cell
101, 671-684 (2000). REVIEWS
Chisholm, A. & Tessier-Lavigne, M. Conservation and divergence of axon guidance mechanisms. Curr. Opin. Neurobiol. 9,603-615 (1999). [PUBMED]
Mueller, B. K. Growth cone guidance: first steps
towards a deeper understanding. Annu. Rev. Neurosci. 22, 351-388 (1999). [Publisher’s site]
Seeger, M. A. & Beattie, C. E. Attraction versus
repulsion: modular receptors make the difference in axon guidance. Cell 9, 821-824 (1999). [PUBMED] tessier-Lavigne, M. & Goodman, C. S. The molecular
biology of axon guidance. Science 274, 1123-1133 (1996). [PUBMED]
Further reading
Yamakawa et al. DSCAM: a novel member of the
immunoglobulin superfamily maps in a Down syndrome region and is
involved in the development of the nervous system. Hum. Mol. Genet. 7:227-237 (1998).
新思路
新技术—其他文章, 百拇医药
提出一新观点，指出果蝇轴突导向中确有信号分子受体的作用存在。
人类唐氏综合症细胞粘连分子在果蝇中的同源物是Dacam，它与Dock相互作用，进而得到分离，Dscam是免疫球蛋白超家族中的一员，其结构与许多常见的轴突导向受体相似。Schmucker etal.发现，Dscam在轴突中表达，其突变体会引起导向出现缺陷，而Dscam的基因结构更是让人大吃一惊，Dscam基因具有相当多的剪切方式，形成蛋白千变万化，但都有相同的结构域，如果每种剪切方式都产生蛋白，那么将有38,000种之多，在神经系统尚未发现这种好象免疫抗体类蛋白才会有的现象。
Dscam好象是探测器的接收器，那么谁是派出的探测器呢?Dscam的配体还未确定。它的人类同源物也是轴突导向受体吗?
The peripheral
nervous system (green processes) in a Drosophila embryo. The green
shadow in the background corresponds to the central nervous system. (Photograph courtesy of J. R. Riesgo, Instituto de Neurobiología,UNAM, Mexico).
相关文章：
Original research paper
Schmucker, D. et al. Drosophila Dscam is an axon
guidance receptor exhibiting extraordinary molecular diversity. Cell
101, 671-684 (2000). REVIEWS
Chisholm, A. & Tessier-Lavigne, M. Conservation and divergence of axon guidance mechanisms. Curr. Opin. Neurobiol. 9,603-615 (1999). [PUBMED]
Mueller, B. K. Growth cone guidance: first steps
towards a deeper understanding. Annu. Rev. Neurosci. 22, 351-388 (1999). [Publisher’s site]
Seeger, M. A. & Beattie, C. E. Attraction versus
repulsion: modular receptors make the difference in axon guidance. Cell 9, 821-824 (1999). [PUBMED] tessier-Lavigne, M. & Goodman, C. S. The molecular
biology of axon guidance. Science 274, 1123-1133 (1996). [PUBMED]
Further reading
Yamakawa et al. DSCAM: a novel member of the
immunoglobulin superfamily maps in a Down syndrome region and is
involved in the development of the nervous system. Hum. Mol. Genet. 7:227-237 (1998).
新思路
新技术—其他文章, 百拇医药