雌激素疗法不能预防老年痴呆病
路透社健康消息 三月份的《神经病学档案》上一项新的研究称，雌激素替代疗法似乎不能降低女性患上老年痴呆病的风险。
老年痴呆病是一种大脑退行性疾病，患者会出现痴呆，最终死亡，15%的老年妇女会患上这种疾病。雌激素疗法可以预防心脏病和骨质疏松症，所以许多妇女在绝经后都使用。但现在还没有足够的证据显示，雌激素疗法能降低老年痴呆病的风险。
美国波士顿大学医学院的研究员追踪两组年龄相近的妇女，一组是112,481名至少接受了一次雌激素治疗的妇女，另一组是108,925名从未接受过雌激素治疗的妇女。结果在两组妇女中共发现了59例老年痴呆病，是否使用雌激素疗法与老年痴呆病的发病风险没有关系。
该发现显示，妇女绝经后使用雌激素替代疗法与患老年痴呆病风险的实质性降低并没有联系。因此，不应该提倡用雌激素替代疗法预防老年痴呆病。
Estrogen Therapy Unlikely to Cut Alzheimer‘s Risk
NEW YORK (Reuters Health) - Women taking estrogen replacement therapy are not likely to cut their risk of developing Alzheimer‘s disease (news - web sites), according to results of a new study.
Alzheimer‘s disease, a degenerative brain condition that leads to dementia and eventual death, affects about 15% of older women. While estrogen replacement therapy--which many women take after menopause--is known to protect against heart disease and osteoporosis, evidence for its effect on Alzheimer‘s disease risk has been equivocal.
Dr. Sudha Seshadri of Boston University School of Medicine in Massachusetts and colleagues followed 112,481 women who had received at least one prescription for estrogen and 108,925 similarly aged women who had not used estrogen therapy.
The researchers report their findings in the March issue of Archives of Neurology.
The investigators found 59 cases of Alzheimer‘s disease in both groups. They found no correlation between whether a woman took estrogen and her Alzheimer‘s disease risk, even among women who had taken the hormone for 5 years or longer.
``Our findings indicate that estrogen replacement therapy use in postmenopausal women is not associated with a substantially reduced risk of Alzheimer‘s disease, and highlights the need for restraint in advocating postmenopausal estrogen replacement therapy for this purpose,‘‘ Seshadri and colleagues conclude., 百拇医药
老年痴呆病是一种大脑退行性疾病，患者会出现痴呆，最终死亡，15%的老年妇女会患上这种疾病。雌激素疗法可以预防心脏病和骨质疏松症，所以许多妇女在绝经后都使用。但现在还没有足够的证据显示，雌激素疗法能降低老年痴呆病的风险。
美国波士顿大学医学院的研究员追踪两组年龄相近的妇女，一组是112,481名至少接受了一次雌激素治疗的妇女，另一组是108,925名从未接受过雌激素治疗的妇女。结果在两组妇女中共发现了59例老年痴呆病，是否使用雌激素疗法与老年痴呆病的发病风险没有关系。
该发现显示，妇女绝经后使用雌激素替代疗法与患老年痴呆病风险的实质性降低并没有联系。因此，不应该提倡用雌激素替代疗法预防老年痴呆病。
Estrogen Therapy Unlikely to Cut Alzheimer‘s Risk
NEW YORK (Reuters Health) - Women taking estrogen replacement therapy are not likely to cut their risk of developing Alzheimer‘s disease (news - web sites), according to results of a new study.
Alzheimer‘s disease, a degenerative brain condition that leads to dementia and eventual death, affects about 15% of older women. While estrogen replacement therapy--which many women take after menopause--is known to protect against heart disease and osteoporosis, evidence for its effect on Alzheimer‘s disease risk has been equivocal.
Dr. Sudha Seshadri of Boston University School of Medicine in Massachusetts and colleagues followed 112,481 women who had received at least one prescription for estrogen and 108,925 similarly aged women who had not used estrogen therapy.
The researchers report their findings in the March issue of Archives of Neurology.
The investigators found 59 cases of Alzheimer‘s disease in both groups. They found no correlation between whether a woman took estrogen and her Alzheimer‘s disease risk, even among women who had taken the hormone for 5 years or longer.
``Our findings indicate that estrogen replacement therapy use in postmenopausal women is not associated with a substantially reduced risk of Alzheimer‘s disease, and highlights the need for restraint in advocating postmenopausal estrogen replacement therapy for this purpose,‘‘ Seshadri and colleagues conclude., 百拇医药
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