肥胖激素与眼病
(家庭医生医疗保健网雅文报道)路透社巴尔的摩健康消息-美国研究人员报导：肥胖症激素Leptin可能与糖尿病相关的眼睛疾病有关。leptin水平越高，眼睛疾病越严重。该研究发布在最近的《眼科学及视觉科学研究》上。
Leptin由脂肪细胞和其它组织产生，在人体脂肪储存达到高峰时可传递信号到脑组织以降低食欲。这项针对73位眼睛Leptin水平增高患者新研究发现，无论患者是否伴发糖尿病，都易于发生糖尿病样视网膜病变，该病变可导致视力损害。
耶鲁大学医学院的加里欧博士说，Leptin可能是导致糖尿病视网膜样病变的若干个分子之一，糖尿病人并发的眼睛损伤有时可导致失明。Leptin在这个过程中的作用促使人们去研究它除了对机体食欲、体重调节及肥胖影响外，还有什么作用。
加里欧认博士为，leptin导致眼睛疾病可能与其促进血管生长作用有关。糖尿病早期即可导致血管异常生长，这项研究支持这一观点。作为当前药物研究的热点，Leptin可能帮助人控制体重。然而，大部份肥胖的人leptin水平不但不低，反而很高，他们可能已经失去了对激素的敏感性。因此单纯给超重的人们给予leptin可能不会刺激重量下降，但基于leptin的治疗可能对治疗糖尿病眼睛疾病是利的。
, 百拇医药
目前，对于糖尿病相关的眼睛疾病尚没有什么治疗方法，这项研究是寻找与糖尿病眼睛疾病有关的不同分子的众多研究一部份，期望最后能开发出高效高特异性的药物来防治该疾病。
来源：《眼科学及视觉科学研究》2000 年11月
‘Obesity Hormone‘ Linked to Eye Disease
BALTIMORE (Reuters Health) - Leptin, the ``obesity hormone,‘‘ may also play a role in diabetes-related eye disease, researchers report.
Leptin is produced by fat cells and other tissue, and is thought to signal the brain to reduce appetite when fat stores are at peak level. In a new study of 73 people with and without diabetes, those who had higher leptin levels in the eye were more likely to have diabetic retinopathy, an eyesight-damaging condition.
, 百拇医药
``Leptin may be one of several molecules that act together to cause diabetic retinopathy, an eye condition sometimes experienced by people with diabetes that can result in blindness,‘‘ Dr. Ray Gariano told Reuters Health. ``Leptin‘s role in this process may help encourage other investigations into its action in the body outside of appetite, weight regulation and obesity.‘‘
Gariano, from Yale University School of Medicine in New Haven, Connecticut, and colleagues found that the more severe the eye disease, the higher the leptin level. The study is reported in the current issue of Investigative Ophthalmology and Visual Science.
, http://www.100md.com
Gariano suggested that leptin may be related to eye disease because it causes blood vessels to grow. ``We know that abnormal blood vessel growth occurs in more advanced stages of diabetic eye disease, and our study supports this idea,‘‘ he said.
Leptin is currently being investigated as a target for drugs that might help people control their weight. However, most obese people have too much leptin, not too little. Many people appear to lose their sensitivity to the hormone, so studies suggest that merely giving leptin to overweight people will probably not spur weight loss.
, http://www.100md.com
According to Gariano, leptin-based therapies might be useful for interrupting diabetic eye disease.
``Presently, there is no therapy for eye disease based on the findings in our paper,‘‘ Gariano said. ``However, our work is part of a larger effort to identify the many different molecules that combine to cause diabetic eye disease, in the hope that we may eventually develop more complete and specific drugs to prevent the disease.‘‘
SOURCE: Investigative Ophthalmology and Visual Science November 2000., http://www.100md.com
Leptin由脂肪细胞和其它组织产生，在人体脂肪储存达到高峰时可传递信号到脑组织以降低食欲。这项针对73位眼睛Leptin水平增高患者新研究发现，无论患者是否伴发糖尿病，都易于发生糖尿病样视网膜病变，该病变可导致视力损害。
耶鲁大学医学院的加里欧博士说，Leptin可能是导致糖尿病视网膜样病变的若干个分子之一，糖尿病人并发的眼睛损伤有时可导致失明。Leptin在这个过程中的作用促使人们去研究它除了对机体食欲、体重调节及肥胖影响外，还有什么作用。
加里欧认博士为，leptin导致眼睛疾病可能与其促进血管生长作用有关。糖尿病早期即可导致血管异常生长，这项研究支持这一观点。作为当前药物研究的热点，Leptin可能帮助人控制体重。然而，大部份肥胖的人leptin水平不但不低，反而很高，他们可能已经失去了对激素的敏感性。因此单纯给超重的人们给予leptin可能不会刺激重量下降，但基于leptin的治疗可能对治疗糖尿病眼睛疾病是利的。
, 百拇医药
目前，对于糖尿病相关的眼睛疾病尚没有什么治疗方法，这项研究是寻找与糖尿病眼睛疾病有关的不同分子的众多研究一部份，期望最后能开发出高效高特异性的药物来防治该疾病。
来源：《眼科学及视觉科学研究》2000 年11月
‘Obesity Hormone‘ Linked to Eye Disease
BALTIMORE (Reuters Health) - Leptin, the ``obesity hormone,‘‘ may also play a role in diabetes-related eye disease, researchers report.
Leptin is produced by fat cells and other tissue, and is thought to signal the brain to reduce appetite when fat stores are at peak level. In a new study of 73 people with and without diabetes, those who had higher leptin levels in the eye were more likely to have diabetic retinopathy, an eyesight-damaging condition.
, 百拇医药
``Leptin may be one of several molecules that act together to cause diabetic retinopathy, an eye condition sometimes experienced by people with diabetes that can result in blindness,‘‘ Dr. Ray Gariano told Reuters Health. ``Leptin‘s role in this process may help encourage other investigations into its action in the body outside of appetite, weight regulation and obesity.‘‘
Gariano, from Yale University School of Medicine in New Haven, Connecticut, and colleagues found that the more severe the eye disease, the higher the leptin level. The study is reported in the current issue of Investigative Ophthalmology and Visual Science.
, http://www.100md.com
Gariano suggested that leptin may be related to eye disease because it causes blood vessels to grow. ``We know that abnormal blood vessel growth occurs in more advanced stages of diabetic eye disease, and our study supports this idea,‘‘ he said.
Leptin is currently being investigated as a target for drugs that might help people control their weight. However, most obese people have too much leptin, not too little. Many people appear to lose their sensitivity to the hormone, so studies suggest that merely giving leptin to overweight people will probably not spur weight loss.
, http://www.100md.com
According to Gariano, leptin-based therapies might be useful for interrupting diabetic eye disease.
``Presently, there is no therapy for eye disease based on the findings in our paper,‘‘ Gariano said. ``However, our work is part of a larger effort to identify the many different molecules that combine to cause diabetic eye disease, in the hope that we may eventually develop more complete and specific drugs to prevent the disease.‘‘
SOURCE: Investigative Ophthalmology and Visual Science November 2000., http://www.100md.com