两病毒相斗 宫颈癌危险减少
路透社纽约健康消息 最近一期《实验与分子病理学》杂志上的一项新的研究发现，感染人乳头状瘤病毒的妇女，如果同时感染腺相关病毒(AAV)，出现宫颈癌前病变的可能性会大大减少。
人乳头状瘤病毒是(HPV)一种通过性传播途径感染的病毒，可引起生殖器疣，人体感染后通常没有明显症状，某些病毒株的感染会增加妇女患宫颈癌的危险。
该研究由美国南卡罗莱纳大学的安妮·柯克博士领导，研究对象包括南卡罗莱纳州300多名在各郡县卫生局接受了例行子宫颈刮片细胞学检查的妇女。
研究发现，其中55名妇女患有重度宫颈糜烂，有高度癌变危险；162名妇女患有轻度宫颈糜烂；96名妇女没有宫颈糜烂。约有71%无宫颈糜烂的妇女和67%宫颈轻度糜烂的妇女被检查出腺相关病毒感染阳性；与此相比，重度宫颈糜烂的妇女被腺相关病毒感染的百分比仅为54%。
, http://www.100md.com
研究小组还发现，携带高水平腺相关病毒的妇女患重度宫颈糜烂的危险性较低，感染人乳头状瘤病毒但没有携带腺相关病毒的妇女普遍都患有重度宫颈糜烂。
研究人员不清楚腺相关病毒到底是怎样减少宫颈糜烂的危险的。他们承认，对腺相关病毒如何起作用的认识目前还处在最初阶段。越来越多的证据表明，这两种病毒也许作用于妇女体内相同的组织，可能以某种形式互相。机体在宫颈糜烂程度较高的状态时会自动清除腺相关病毒，这可以解释为什么那些重度宫颈糜烂的患者较少携带腺相关病毒。
柯克博士认为，腺相关病毒可以干扰人乳头状瘤病毒，可能是通过干扰人乳头状瘤病毒与人体细胞的结合能力，从而阻止癌前病变的发生。在例行做子宫颈刮片细胞学检查的同时筛查人乳头状瘤病毒与腺相关病毒的感染情况，有助于判断患者是否有发展为高度宫颈糜烂的危险。她强调说，必须先明确人乳头状瘤病毒和腺相关病毒之间的关系，而且需要做长期的研究来查明腺相关病毒究竟是怎样干扰妇女体内的人乳头状瘤病毒的。
, 百拇医药
加利福尼亚大学洛杉矶分校琼森癌症研究综合中心的主任，妇产科肿瘤学专家乔纳森·贝克博士把这项研究形容为“有意思的初步研究”。他认为若这一发现能得到证实，将有助医学界对宫颈癌进一步了解，而且对筛查和预防宫颈癌也有帮助。
贝克博士也指出，虽然已经肯定人乳头状瘤病毒和宫颈癌有关系，但目前对于人乳头状瘤病毒的认识也还没有统一的意见。人乳头状瘤病毒的感染率非常普遍，检查该病毒的试验费用昂贵，目前我们仍然没有办法对付它。应该进行一项前瞻性的研究来确定腺相关病毒的具体作用。
Common Virus May Reduce Cervical Cancer Risk
NEW YORK (Reuters Health) - A common virus may interfere with the human papillomavirus (HPV), a sexually transmitted infection linked to cervical cancer, researchers report.
, http://www.100md.com
In a new study, women with HPV who also were infected with the adeno-associated virus (AAV) were less likely to have cervical abnormalities, or lesions, that could become cancerous.
``AAV may interfere with HPV to help protect women from developing precancerous lesions that sometimes develop into cervical cancer,‘‘ the study‘s lead author, Dr. Ann L. Coker, of the University of South Carolina in Columbia, said in a news release.
, 百拇医药 But Coker stressed the need for long-term studies to find out the precise role of AAV in women with HPV.
HPV can cause genital warts, although the infection does not always cause symptoms. Some strains of the virus increase a woman‘s risk of cervical cancer.
Coker‘s study included more than 300 South Carolina women who received routine Pap smears at county health departments. Fifty-five had high-grade cervical lesions, meaning the abnormalities had a high risk of becoming cancerous; 162 women had low-grade lesions and 96 were lesion-free.
, 百拇医药
Nearly 71% of women without cervical lesions and 67% of women with low-grade lesions tested positive for AAV, Coker and her colleagues report in the April issue of the journal Experimental and Molecular Pathology. AAV infection was present in only about 54% of women with high-grade lesions. 以
Coker‘s team also found that women with higher levels of AAV had a lower risk of high-grade lesions, and that high-grade lesions were most common in women who had HPV but did not have AAV.
, 百拇医药
Screening for HPV and AAV at the time of a routine Pap smear may help identify women at increased risk of developing high-grade lesions, according to the investigators. However, the authors caution that the relationship between AAV and HPV needs to be confirmed first.
The researchers are not sure how AAV may reduce the risk of cervical lesions. More and more evidence suggests that AAV and HPV infect the same tissue in women, so the two viruses may interact in some way, the report indicates.
, 百拇医药
AAV ``may interfere with high-risk HPV‘s ability to integrate into human cells,‘‘ Coker told Reuters Health in an interview. But Coker cautioned that the exact role of AAV remains uncertain. ``We‘re really just in the early stages of understanding what it does,‘‘ she said.
Coker and her colleagues caution that the body could eliminate AAV as high-grade lesions form, which would explain why women with these abnormalities seem to be less likely to carry the virus.
, 百拇医药
The study is ``interesting preliminary research,‘‘ according to Dr. Jonathan Berek, chief of gynecologic oncology at the Jonsson Comprehensive Cancer Center at the University of California, Los Angeles.
If confirmed, the findings may lead to a better understanding of cervical cancer, and perhaps improved screening for and prevention of the disease, he told Reuters Health.
But Berek cautioned that there is still no consensus on screening for HPV, which is definitely linked to cervical cancer. ``We still haven‘t figured out what to do with the first virus,‘‘ he said. He noted that infection with HPV is very common and testing for the virus is expensive.
Coker and her colleagues hope to conduct a prospective study that would follow women over time to determine the precise role of AAV., 百拇医药
人乳头状瘤病毒是(HPV)一种通过性传播途径感染的病毒，可引起生殖器疣，人体感染后通常没有明显症状，某些病毒株的感染会增加妇女患宫颈癌的危险。
该研究由美国南卡罗莱纳大学的安妮·柯克博士领导，研究对象包括南卡罗莱纳州300多名在各郡县卫生局接受了例行子宫颈刮片细胞学检查的妇女。
研究发现，其中55名妇女患有重度宫颈糜烂，有高度癌变危险；162名妇女患有轻度宫颈糜烂；96名妇女没有宫颈糜烂。约有71%无宫颈糜烂的妇女和67%宫颈轻度糜烂的妇女被检查出腺相关病毒感染阳性；与此相比，重度宫颈糜烂的妇女被腺相关病毒感染的百分比仅为54%。
, http://www.100md.com
研究小组还发现，携带高水平腺相关病毒的妇女患重度宫颈糜烂的危险性较低，感染人乳头状瘤病毒但没有携带腺相关病毒的妇女普遍都患有重度宫颈糜烂。
研究人员不清楚腺相关病毒到底是怎样减少宫颈糜烂的危险的。他们承认，对腺相关病毒如何起作用的认识目前还处在最初阶段。越来越多的证据表明，这两种病毒也许作用于妇女体内相同的组织，可能以某种形式互相。机体在宫颈糜烂程度较高的状态时会自动清除腺相关病毒，这可以解释为什么那些重度宫颈糜烂的患者较少携带腺相关病毒。
柯克博士认为，腺相关病毒可以干扰人乳头状瘤病毒，可能是通过干扰人乳头状瘤病毒与人体细胞的结合能力，从而阻止癌前病变的发生。在例行做子宫颈刮片细胞学检查的同时筛查人乳头状瘤病毒与腺相关病毒的感染情况，有助于判断患者是否有发展为高度宫颈糜烂的危险。她强调说，必须先明确人乳头状瘤病毒和腺相关病毒之间的关系，而且需要做长期的研究来查明腺相关病毒究竟是怎样干扰妇女体内的人乳头状瘤病毒的。
, 百拇医药
加利福尼亚大学洛杉矶分校琼森癌症研究综合中心的主任，妇产科肿瘤学专家乔纳森·贝克博士把这项研究形容为“有意思的初步研究”。他认为若这一发现能得到证实，将有助医学界对宫颈癌进一步了解，而且对筛查和预防宫颈癌也有帮助。
贝克博士也指出，虽然已经肯定人乳头状瘤病毒和宫颈癌有关系，但目前对于人乳头状瘤病毒的认识也还没有统一的意见。人乳头状瘤病毒的感染率非常普遍，检查该病毒的试验费用昂贵，目前我们仍然没有办法对付它。应该进行一项前瞻性的研究来确定腺相关病毒的具体作用。
Common Virus May Reduce Cervical Cancer Risk
NEW YORK (Reuters Health) - A common virus may interfere with the human papillomavirus (HPV), a sexually transmitted infection linked to cervical cancer, researchers report.
, http://www.100md.com
In a new study, women with HPV who also were infected with the adeno-associated virus (AAV) were less likely to have cervical abnormalities, or lesions, that could become cancerous.
``AAV may interfere with HPV to help protect women from developing precancerous lesions that sometimes develop into cervical cancer,‘‘ the study‘s lead author, Dr. Ann L. Coker, of the University of South Carolina in Columbia, said in a news release.
, 百拇医药 But Coker stressed the need for long-term studies to find out the precise role of AAV in women with HPV.
HPV can cause genital warts, although the infection does not always cause symptoms. Some strains of the virus increase a woman‘s risk of cervical cancer.
Coker‘s study included more than 300 South Carolina women who received routine Pap smears at county health departments. Fifty-five had high-grade cervical lesions, meaning the abnormalities had a high risk of becoming cancerous; 162 women had low-grade lesions and 96 were lesion-free.
, 百拇医药
Nearly 71% of women without cervical lesions and 67% of women with low-grade lesions tested positive for AAV, Coker and her colleagues report in the April issue of the journal Experimental and Molecular Pathology. AAV infection was present in only about 54% of women with high-grade lesions. 以
Coker‘s team also found that women with higher levels of AAV had a lower risk of high-grade lesions, and that high-grade lesions were most common in women who had HPV but did not have AAV.
, 百拇医药
Screening for HPV and AAV at the time of a routine Pap smear may help identify women at increased risk of developing high-grade lesions, according to the investigators. However, the authors caution that the relationship between AAV and HPV needs to be confirmed first.
The researchers are not sure how AAV may reduce the risk of cervical lesions. More and more evidence suggests that AAV and HPV infect the same tissue in women, so the two viruses may interact in some way, the report indicates.
, 百拇医药
AAV ``may interfere with high-risk HPV‘s ability to integrate into human cells,‘‘ Coker told Reuters Health in an interview. But Coker cautioned that the exact role of AAV remains uncertain. ``We‘re really just in the early stages of understanding what it does,‘‘ she said.
Coker and her colleagues caution that the body could eliminate AAV as high-grade lesions form, which would explain why women with these abnormalities seem to be less likely to carry the virus.
, 百拇医药
The study is ``interesting preliminary research,‘‘ according to Dr. Jonathan Berek, chief of gynecologic oncology at the Jonsson Comprehensive Cancer Center at the University of California, Los Angeles.
If confirmed, the findings may lead to a better understanding of cervical cancer, and perhaps improved screening for and prevention of the disease, he told Reuters Health.
But Berek cautioned that there is still no consensus on screening for HPV, which is definitely linked to cervical cancer. ``We still haven‘t figured out what to do with the first virus,‘‘ he said. He noted that infection with HPV is very common and testing for the virus is expensive.
Coker and her colleagues hope to conduct a prospective study that would follow women over time to determine the precise role of AAV., 百拇医药