格鲁恩兹发明冠状动脉球囊扩张术的故事
23年前，瑞士医生安德鲁斯·格鲁恩兹(Dr. Andreas Gruentzig)紧张地把一根前端带有球囊的导管插入到病人阿杜夫·巴曼心脏的一条动脉里面，扩张球囊，使动脉恢复通畅，完成了医学界首例冠状动脉球囊扩张术，巴曼也成了世界上第一位接受冠状动脉球囊扩张术病人被载入了医学界的史册。据近期的《新英格兰医学杂志》报导，直至去年四月对巴曼进行的一次体检表明，他心脏的血管依然血液通畅。
巴曼是在38岁时得知格鲁恩兹医生发明了这种非外科治疗方法，这种治疗方法原来只用于大腿动脉，从来没有在心脏血管上使用过。治疗过程是把一根细小的导管插入到病变动脉里，然后向导管末端的球囊充气，利用膨胀的球囊把堵在动脉血管中的血凝块挤碎。据说格鲁恩兹医生是在自家的厨房里发明设计了手术模型。
1977年9月16日格鲁恩兹顶着来自上司多方面的怀疑和反对压力，在瑞士苏黎世大学医院为巴曼做了冠状动脉球囊扩张术。他当时非常紧张，因为他根本没有失败的余地。巴曼可能是当时在场者中最镇静的一人，但这并不是因为他本身是个很镇静的人，而是因为他被注射了镇静剂。术后，巴曼所有的症状都消失了，他戒了烟并很快不需要服用治疗心脏病的药物。
, 百拇医药
在1977年的美国心脏病协会会议上，格鲁恩兹展示了他的最初所做的四例冠状动脉球囊扩张术的成功结果，获得了长时间的欢呼和掌声。当时格鲁恩兹非常谦虚，他认为冠状动脉球囊扩张术的疗效是暂时的，可能只是推迟心脏旁路手术的一种方法。
的确，早期几乎有1/3的患者在术后一年内重新出现动脉堵塞现象，但如今这个数字已减少到了15%-25%，而且在经常这种手术的医院里接受冠状动脉球囊扩张术对心脏病患者来说快捷便利的，是目前为止最好的治疗方法。如今，仅在美国每年就有70万病人接受该手术。
格鲁恩兹于1985年逝世，但人们永远不会忘记他的这一创举，他造福了无数冠心病患者。
First Angioplasty a Success Story
Twenty-three years after Dr. Andreas Gruentzig of Switzerland nervously made medical history by threading a balloon-tipped tube into an artery supplying Adolph Bachman‘s heart, the blood vessel is still unclogged.
, http://www.100md.com
An exam done last April on Bachman showed that blood was flowing freely, according to a report in Thursday‘s New England Journal of Medicine (news - web sites) on the world‘s first balloon angioplasty - a procedure that is now performed about 700,000 times a year in the United States alone.
Bachman was 38 when he was told that Gruentzig had an alternative to bypass surgery. It was a treatment that had worked in leg arteries but had never been tried on the heart: inserting a tiny catheter into the artery, then blowing up a balloon at the end to squash the blood clot blocking it. Gruentzig had designed the prototypes in his kitchen.
, http://www.100md.com
Gruentzig did Bachman‘s angioplasty on Sept. 16, 1977, at University Hospital in Zurich, Switzerland, despite great skepticism from others and resistance from his superiors, said Dr. Valentin Fuster, whom Gruentzig consulted.
``Andreas was very tense,‘‘ Dr. Bernhard Meier, Bachman‘s physician, said in a video made to commemorate the procedure‘s 20th anniversary. ``There was simply no room for failure in the first patient, considering the circumstances.‘‘
, http://www.100md.com
The video shows Bachman saying, ``I was probably the calmest person in the room. But not because I‘m an especially calm person, but because I was given sedatives and medicines.‘‘
The angioplasty eliminated all of Bachman‘s symptoms, Meier wrote in the journal report. The patient quit smoking and soon stopped taking all his cardiac medications. A few years ago, he began taking aspirin and cholesterol-lowering drugs.
Gruentzig died in 1985.
, http://www.100md.com
That the artery is still clear ``really pays tribute to this innovative approach of Dr. Gruentzig,‘‘ said Fuster, director of the Cardiovascular Institute at Mount Sinai School of Medicine in New York and former president of the American Heart Association (news - web sites).
When Gruentzig presented results of his first four angioplasties at an American Heart Association meeting in 1977, he got a standing ovation. Fuster said Gruentzig believed that the benefits of angioplasty would be temporary, perhaps postponing the need for a bypass. ``His comments were rather humble,‘‘ Fuster said.
Nearly one-third of the early patients‘ arteries clogged again within a year. That is now down to 15 percent to 25 percent, and angioplasty is considered the best treatment for heart attack patients if done promptly at hospitals that perform the procedure often., 百拇医药
巴曼是在38岁时得知格鲁恩兹医生发明了这种非外科治疗方法，这种治疗方法原来只用于大腿动脉，从来没有在心脏血管上使用过。治疗过程是把一根细小的导管插入到病变动脉里，然后向导管末端的球囊充气，利用膨胀的球囊把堵在动脉血管中的血凝块挤碎。据说格鲁恩兹医生是在自家的厨房里发明设计了手术模型。
1977年9月16日格鲁恩兹顶着来自上司多方面的怀疑和反对压力，在瑞士苏黎世大学医院为巴曼做了冠状动脉球囊扩张术。他当时非常紧张，因为他根本没有失败的余地。巴曼可能是当时在场者中最镇静的一人，但这并不是因为他本身是个很镇静的人，而是因为他被注射了镇静剂。术后，巴曼所有的症状都消失了，他戒了烟并很快不需要服用治疗心脏病的药物。
, 百拇医药
在1977年的美国心脏病协会会议上，格鲁恩兹展示了他的最初所做的四例冠状动脉球囊扩张术的成功结果，获得了长时间的欢呼和掌声。当时格鲁恩兹非常谦虚，他认为冠状动脉球囊扩张术的疗效是暂时的，可能只是推迟心脏旁路手术的一种方法。
的确，早期几乎有1/3的患者在术后一年内重新出现动脉堵塞现象，但如今这个数字已减少到了15%-25%，而且在经常这种手术的医院里接受冠状动脉球囊扩张术对心脏病患者来说快捷便利的，是目前为止最好的治疗方法。如今，仅在美国每年就有70万病人接受该手术。
格鲁恩兹于1985年逝世，但人们永远不会忘记他的这一创举，他造福了无数冠心病患者。
First Angioplasty a Success Story
Twenty-three years after Dr. Andreas Gruentzig of Switzerland nervously made medical history by threading a balloon-tipped tube into an artery supplying Adolph Bachman‘s heart, the blood vessel is still unclogged.
, http://www.100md.com
An exam done last April on Bachman showed that blood was flowing freely, according to a report in Thursday‘s New England Journal of Medicine (news - web sites) on the world‘s first balloon angioplasty - a procedure that is now performed about 700,000 times a year in the United States alone.
Bachman was 38 when he was told that Gruentzig had an alternative to bypass surgery. It was a treatment that had worked in leg arteries but had never been tried on the heart: inserting a tiny catheter into the artery, then blowing up a balloon at the end to squash the blood clot blocking it. Gruentzig had designed the prototypes in his kitchen.
, http://www.100md.com
Gruentzig did Bachman‘s angioplasty on Sept. 16, 1977, at University Hospital in Zurich, Switzerland, despite great skepticism from others and resistance from his superiors, said Dr. Valentin Fuster, whom Gruentzig consulted.
``Andreas was very tense,‘‘ Dr. Bernhard Meier, Bachman‘s physician, said in a video made to commemorate the procedure‘s 20th anniversary. ``There was simply no room for failure in the first patient, considering the circumstances.‘‘
, http://www.100md.com
The video shows Bachman saying, ``I was probably the calmest person in the room. But not because I‘m an especially calm person, but because I was given sedatives and medicines.‘‘
The angioplasty eliminated all of Bachman‘s symptoms, Meier wrote in the journal report. The patient quit smoking and soon stopped taking all his cardiac medications. A few years ago, he began taking aspirin and cholesterol-lowering drugs.
Gruentzig died in 1985.
, http://www.100md.com
That the artery is still clear ``really pays tribute to this innovative approach of Dr. Gruentzig,‘‘ said Fuster, director of the Cardiovascular Institute at Mount Sinai School of Medicine in New York and former president of the American Heart Association (news - web sites).
When Gruentzig presented results of his first four angioplasties at an American Heart Association meeting in 1977, he got a standing ovation. Fuster said Gruentzig believed that the benefits of angioplasty would be temporary, perhaps postponing the need for a bypass. ``His comments were rather humble,‘‘ Fuster said.
Nearly one-third of the early patients‘ arteries clogged again within a year. That is now down to 15 percent to 25 percent, and angioplasty is considered the best treatment for heart attack patients if done promptly at hospitals that perform the procedure often., 百拇医药
参见：首页 > 医疗版 > 疾病专题 > 心血管科 > 冠状动脉病