饮酒和低叶酸摄入与乳腺癌有关
路透社纽约健康消息 对于大多数妇女来说，低叶酸摄入并不是乳腺癌的主要风险因素，但也有例外，就是那些叶酸摄入低而又常饮酒的女性。一项新研究表明：绝经后妇女如果每天饮酒半杯以上且B族维生素叶酸摄入量不足，她们乳腺癌发病危险比那些不饮酒、高叶酸摄入的妇女高59%。
由美国明尼苏达州罗彻斯特市梅奥医学中心托马斯·A·赛乐斯博士领导的研究小组调查了34,000多位绝经后妇女，评估她们的食谱和维生素摄入量等生活方式和健康的关系。12年后发现，将近1,600 妇女出现了乳腺癌。每天饮酒最多但叶酸摄入最高的妇女与不饮酒、叶酸摄入低的妇女有相同的乳腺癌风险。
饮酒能轻度增加乳腺癌的风险，因为酒精会在体内被分解成乙醛，而乙醛已以被证实是致癌物质。这项研究的结果表明，如果机体有足够叶酸，适度地饮酒不会增加乳腺癌的风险。叶酸可能是机体修复会致癌的缺陷基因的重要物质。
因此，赛洛乐斯博士建议，有饮酒习惯的妇女要注意补充叶酸。含叶酸丰富的食物包括绿色有叶蔬菜、橙汁、干豆、豌豆，以及营养强化型谷物。
, 百拇医药
来源：《流行病学》2001;11
Drinking Plus Low Folate Linked to Breast Cancer
NEW YORK (Reuters Health) - Postmenopausal women who drink more than a half a glass of alcohol per day and have low intakes of the B vitamin folate may be at increased risk of breast cancer, a new study suggests.
The researchers found that these women were 59% more likely to develop breast cancer than those who did not drink alcohol and had the highest intake of folate.
, 百拇医药
For most women, low B-vitamin intakes do not represent a major risk factor for breast cancer. In this study, the exception was among women who consumed little folate, but regularly drank alcohol, report Dr. Thomas A. Sellers of the Mayo Clinic in Rochester, Minnesota, and colleagues.
Alcohol use has been linked to a slight increase in the risk for breast cancer. And folate may be an important part of the body‘s capacity to repair the genetic damage that can lead to cancer, the researchers note in the July issue of the journal Epidemiology.
, http://www.100md.com
Sellers explained that alcohol is broken down in the body into a chemical called acetaldehyde, which has been shown to cause cancer. Without adequate folate, the body may not be able to undo the harm caused by alcohol.
``This study adds to the growing body of evidence that if you have adequate levels of folate in the body, you are not increasing your risk of breast cancer by drinking in moderation,‘‘ he told Reuters Health.
The team of researchers reviewed information on more than 34,000 postmenopausal women and assessed a range of health and lifestyle factors including diet and vitamin intake. After 12 years, nearly 1,600 women had developed breast cancer.
, http://www.100md.com
Women who drank the most alcohol each day but who consumed the highest level of folate had about the same risk of breast cancer as women who did not drink alcohol and had low intakes of folate, according to the report.
``It is well established that the use of alcohol-containing beverages poses a slight increase in the risk of breast cancer,‘‘ Sellers said in a prepared statement. ``People who have adequate folate intake, however, may have a better capacity to repair DNA damage caused by acetaldehyde.‘‘
He said women who consume alcohol on a weekly basis may want to consider a folate supplement if they believe their blood levels of the vitamin are low.
Folate-rich foods include green leafy vegetables, orange juice, dried beans and peas, and fortified cereals.
SOURCE: Epidemiology 2001;11., http://www.100md.com
由美国明尼苏达州罗彻斯特市梅奥医学中心托马斯·A·赛乐斯博士领导的研究小组调查了34,000多位绝经后妇女，评估她们的食谱和维生素摄入量等生活方式和健康的关系。12年后发现，将近1,600 妇女出现了乳腺癌。每天饮酒最多但叶酸摄入最高的妇女与不饮酒、叶酸摄入低的妇女有相同的乳腺癌风险。
饮酒能轻度增加乳腺癌的风险，因为酒精会在体内被分解成乙醛，而乙醛已以被证实是致癌物质。这项研究的结果表明，如果机体有足够叶酸，适度地饮酒不会增加乳腺癌的风险。叶酸可能是机体修复会致癌的缺陷基因的重要物质。
因此，赛洛乐斯博士建议，有饮酒习惯的妇女要注意补充叶酸。含叶酸丰富的食物包括绿色有叶蔬菜、橙汁、干豆、豌豆，以及营养强化型谷物。
, 百拇医药
来源：《流行病学》2001;11
Drinking Plus Low Folate Linked to Breast Cancer
NEW YORK (Reuters Health) - Postmenopausal women who drink more than a half a glass of alcohol per day and have low intakes of the B vitamin folate may be at increased risk of breast cancer, a new study suggests.
The researchers found that these women were 59% more likely to develop breast cancer than those who did not drink alcohol and had the highest intake of folate.
, 百拇医药
For most women, low B-vitamin intakes do not represent a major risk factor for breast cancer. In this study, the exception was among women who consumed little folate, but regularly drank alcohol, report Dr. Thomas A. Sellers of the Mayo Clinic in Rochester, Minnesota, and colleagues.
Alcohol use has been linked to a slight increase in the risk for breast cancer. And folate may be an important part of the body‘s capacity to repair the genetic damage that can lead to cancer, the researchers note in the July issue of the journal Epidemiology.
, http://www.100md.com
Sellers explained that alcohol is broken down in the body into a chemical called acetaldehyde, which has been shown to cause cancer. Without adequate folate, the body may not be able to undo the harm caused by alcohol.
``This study adds to the growing body of evidence that if you have adequate levels of folate in the body, you are not increasing your risk of breast cancer by drinking in moderation,‘‘ he told Reuters Health.
The team of researchers reviewed information on more than 34,000 postmenopausal women and assessed a range of health and lifestyle factors including diet and vitamin intake. After 12 years, nearly 1,600 women had developed breast cancer.
, http://www.100md.com
Women who drank the most alcohol each day but who consumed the highest level of folate had about the same risk of breast cancer as women who did not drink alcohol and had low intakes of folate, according to the report.
``It is well established that the use of alcohol-containing beverages poses a slight increase in the risk of breast cancer,‘‘ Sellers said in a prepared statement. ``People who have adequate folate intake, however, may have a better capacity to repair DNA damage caused by acetaldehyde.‘‘
He said women who consume alcohol on a weekly basis may want to consider a folate supplement if they believe their blood levels of the vitamin are low.
Folate-rich foods include green leafy vegetables, orange juice, dried beans and peas, and fortified cereals.
SOURCE: Epidemiology 2001;11., http://www.100md.com