胃泌素受体作为分子靶向在肿瘤中的表达及应用
胃泌素;胃泌素受体;肿瘤,江春平,丁义涛,孔诚,通讯作者:,Expressionofgastrinreceptorintumorsanditsapplicationasamoleculartargetforcancerdiagnosisandthe
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江春平, 丁义涛, 南京大学医学院附属鼓楼医院肝胆外科 江苏省南京市 210008
孔诚, 江苏省肿瘤医院 江苏省南京市 210009
卫生部重点课题, No. WKJ2005-2-032
通讯作者: 丁义涛, 210008, 江苏省南京市中山路321号, 南京大学医学院附属鼓楼医院肝胆外科. dingyitao@yahoo.com.cn
电话: 025-83304616-11902
收稿日期: 2006-09-18 接受日期: 2006-11-16
Expression of gastrin receptor in tumors and its application as a molecular target for cancer diagnosis and therapy
Chun-Ping Jiang, Cheng Kong, Yi-Tao Ding
Chun-Ping Jiang, Yi-Tao Ding,Department of Hepatobillary Surgery, Nanjing Drum Tower Hospital, Medical College of Nanjing University, Nanjing 210008, Jiangsu Province, China
Cheng Kong,Jiangsu Cancer Hospital, Nanjing 210009, Jiangsu Province, China
Supported by the Fund from Ministry of Health in China, No. WKJ2005-2-032
Correspondence to:Yi-Tao Ding, Department of Hepatobillary Surgery, Nanjing Drum Tower Hospital, Medical College of Nanjing University, 321 Zhongshan Road, Nanjing 210008, Jiangsu Province, China. dingyitao@yahoo.com.cn
Received:2006-09-18 Accepted:2006-11-16
Abstract
Gastrin is widely distributed in gastrointestinal tract and pancreatic tissues, and it plays important roles in the modulation of physiological functions and pathogenic mechanism of some diseases. Recent studies showed that gastrin might promote the pathogenesis and growth of tumors, especially digestive tumors such as gastric cancer and colorectal cancer. The biological effect of gastrin is mainly mediated by cholecystokinin (CCK) receptors. Gastrin mRNA has been found in CCK-receptor positive small-cell lung carcinoma, breast cancer, ovarian cancer and cancer stem cells of various origins and it may serve as the indicator of self-secretive regulation. The tumors with over-expressed gastin receptor can be diagnosed and treated by radiolabelling or linking to the cytotoxic agents with gastin peptide and analogs, and scintigraphy was used to visualize the image in vivo ......
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