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蛋白芯片检测多肿瘤标志物对原发性肝癌的诊断价值评价
http://www.100md.com 2007年3月28日 周秀艳, 侯振江, 邢桂芝
原发性肝癌;肿瘤标志物;蛋白芯片,周秀艳,侯振江,邢桂芝,通讯作者:,Valuesofmulti-tumormarkerprotein-chipdiagnosticsysteminthediagnosisofprimaryhepatic
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     周秀艳, 河北省唐山市人民医院检验科 河北省唐山市 063001

    侯振江,
沧州医学高等专科学校 河北省沧州市 061001

    邢桂芝,
唐山市工人医院检验科 河北省唐山市 063000

    河北省科学技术发展和规划项目, No. 052761288

    通讯作者:
周秀艳, 063001, 河北省唐山市, 唐山市人民医院检验科. zhouxiuyan6666@sina.com

    电话: 0315-2875147

    收稿日期: 2006-11-22 接受日期: 2007-01-20

    Values of multi-tumor marker protein-chip diagnostic system in the diagnosis of primary hepatic cancer

    
Xiu-Yan Zhou, Zhen-Jiang Hou, Gui-Zhi Xing

    Xiu-Yan Zhou,
Department of Clinical Laboratory, Tangshan People’s Hospital, Tangshan 063001, Hebei Province, China

    Zhen-Jiang Hou,
Cangzhou Medical College, Cangzhou 061001, Hebei Province, China

    Gui-Zhi Xing,
Department of Clinical Laboratory, Tangshan Worker’s Hospital, Tangshan 063000, Hebei Province, China

    Correspondence to:
Xiu-Yan Zhou, Department of Clinical Laboratory, Tangshan People’s Hospital, Tangshan 063001, Hebei Province, China. zhouxiuyan6666@sina.com

    Received:
2006-11-22 Accepted:2007-01-20

    Abstract

    AIM: To discuss the diagnostic values of multi-tumor marker protein-chip diagnostic system for primary hepatic cancer (PHC).

    METHODS: By the multi-tumor-marker protein-chip diagnostic system, we detected 12 kinds of tumor indicators, which included carbohydrate antigen 199 (CA199), alphafetoprotein (AFP), neuron-specific enolase (NSE), free prostate specific antigen (f-PSA), carcinoembryonic antigen (CEA), prostate specific antigen (PSA), carbohydrate antigen 242 (CA242), carbohydrate antigen 125 (CA125), carbohydrate antigen 153 (CA153), ferritin (FER), human growth hormone (HGH) and β human chorionic gonadotropin (β-HCG), in 73 cases of PHC, 48 cases of benign hepatic diseases and 40 cases of healthy individuals as controls.

    RESULTS: The positive rates of AFP, CA199, CA125, CEA, CA242, FER and β-HCG were significantly increased in PHC patients in comparison with those in patients with benign hepatic diseases (65 ......

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