胃癌组织中MTA1, PTEN, E-cadherin的表达及其相互关系
胃癌;肿瘤转移相关基因1;PTEN蛋白;上皮型钙黏蛋白,胃癌组织中MTA1,PTEN,E-cadherin的表达及其相互关系,桑海泉,王强,桑海泉,通讯作者:,Expressionofmetastasis-associatedgene1,PTENandE-cadheriningastricc
 |
| 第2页 |
 |
| 第1页 |
参见附件(1006KB，7页)。
桑海泉, 王强, 中国医科大学附属盛京医院胃肠外科 辽宁省沈阳市 110004
桑海泉, 2007年中国医科大学硕士, 主要从事胃癌病因和治疗的基础和临床研究.
通讯作者: 王强, 110004, 辽宁省沈阳市和平区三好街36号, 中国医科大学附属盛京医院胃肠外科. wangq@cmu2h.com
电话: 024-83955060 传真: 024-83955060
收稿日期: 2007-02-01 接受日期: 2007-03-06
Expression of metastasis-associated gene 1, PTEN and E-cadherin in gastric carcinoma and their correlations
Hai-Quan Sang, Qiang Wang
Hai-Quan Sang, Qiang Wang,Department of Gastrointestinal Surgery, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China
Correspondence to:Qiang Wang, Department of Gastrointestinal Surgery, Shengjing Hospital of China Medical University, 36 Sanhao Street, Heping District, Shenyang 110004, Liaoning Province, China. wangq@cmu2h.com
Received:2007-02-01 Accepted:2007-03-06
Abstract
AIM: To investigate the expression of metastasis-associated gene 1 (MTA1), PTEN and E-cadherin in gastric carcinoma and normal gastric mucosa and their relationships with the invasion, metastasis and biological behavior of gastric carcinoma.
METHODS: Immunohistochemistry was used to examine the expression of MTA1, PTEN and E-cadherin proteins in gastric carcinoma (n = 54) and normal gastric mucosa (n = 15). The data were processed by chi-square test and the correlation was analyzed by Spearman test.
RESULTS: In comparison with those in normal gastric mucosa, the expression of MTA1 in gastric carcinoma was significantly higher (46.3%vs 6.7%, P < 0.01), and the expression of PTEN and E-cadherin in gastric carcinoma were down-regulated or even disappeared (51.9% vs 100%, 42.6% vs 100%; both P < 0.01). The expression of MTA1 and PTEN were correlated with the invasion depth (P = 0.003, P = 0.001), pathological grades (P = 0.004, P = 0.008), lymph node metastasis (P = 0.000, P = 0.001), distant metastasis (P = 0.004, P = 0.006) and clinical classification (P = 0 ......
您现在查看是摘要介绍页，详见PDF附件(1006KB，7页)。