多重耐药蛋白-1在胃癌中的表达及意义
胃癌;多耐药相关蛋白;免疫组织化学染色;逆转录-聚合酶链反应,谢家泰,陈宏斌,蒋义贵,徐朝焰,谢家泰,通讯作者:,Expressionandsignificanceofmultidrugresistance-associatedprotein-1inga
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谢家泰, 陈宏斌, 蒋义贵, 徐朝焰, 福建医科大学附属三明第一医院消化内科 福建省三明市 365000
谢家泰, 2006年南华大学硕士, 主要从事胃肠道肿瘤的研究.
通讯作者: 谢家泰, 365000, 福建省三明市, 福建医科大学附属三明第一医院消化内科. gmlxjt@163.com
电话: 0598-8257419 传真: 0598-8234019
收稿日期: 2007-01-20 接受日期: 2007-02-03
Expression and significance of multidrug resistance-associated protein-1 in gastric carcinoma
Jia-Tai Xie, Hong-Bin Chen, Yi-Gui Jiang, Chao-Yan Xu
Jia-Tai Xie, Hong-Bin Chen, Yi-Gui Jiang, Chao-Yan Xu,Department of Gastroenterology, the First Hospital of Sanming City, Fujian Medical University, Sanming 365000, Fujian Province, China
Correspondence to:Jia-Tai Xie, Department of Gastroenterology, the First Hospital of Sanming City, Fujian Medical University, Sanming 365000, Fujian Province, China. gmlxjt@163.com
Received: 2007-01-20 Accepted:2007-02-03
Abstract
AIM: To explore the expression of multidrug resistance-associated protein 1 (MRP-1) in gastric carcinoma and its significance.
METHODS: The expression of MRP-1 were detected by immunohistochemistry (SP method) in 30 cases of chronic superficial gastritis (CSG), 30 cases of gastric intestinal metaplasia (IM), 45 cases of dysplasia (Dys) and 65 cases of gastric carcinoma (GC). Reverse transcription-polymerase chain reaction (RT-PCR) was used to examine the expression of MRP-1 mRNA. The comparison between mean values and rates was performed by t test and χ2 test, respectively, and the relativity between two factors was evaluated by linear relative analysis.
RESULTS: The expression of MRP-1 showed a gradually increasing tendency as the disease progressed from CSG, IM, Dys to GC, and there was significant difference between GC and Dys as well as IM (43/65 vs 19/45, 6/30, P < 0 ......
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