散发性结直肠癌微卫星不稳定性及其与临床病理生物学的关系
散发性结直肠癌;微卫星不稳定;临床病理生物学特征,杨柏林,谷云飞,赖仁胜,谢玲,金黑鹰,通讯作者:,Microsatelliteinstabilityinsporadiccolorectalcanceranditsrelations
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杨柏林, 谷云飞, 南京中医药大学附属医院肛肠科 江苏省南京市 210029
赖仁胜, 谢玲, 南京中医药大学附属医院病理科 江苏省南京市 210029
金黑鹰, 南京中医药大学第三附属医院全国肛肠医疗中心 江苏省南京市 210001
国家自然科学基金资助项目, No. 30572447
通讯作者: 金黑鹰, 210001, 江苏省南京市, 南京中医药大学第三附属医院全国肛肠医疗中心. jinheiying@yahoo.com.cn
收稿日期: 2006-12-15 接受日期: 2007-02-08
Microsatellite instability in sporadic colorectal cancer and its relationship with clinicopathological features
Bo-Lin Yang, Yun-Fei Gu, Ren-Sheng Lai, Ling Xie, Hei-Ying Jin
Bo-Lin Yang, Yun-Fei Gu,Department of Anal and Intestinal Disease, the Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing 210029, Jiangsu Province, China
Ren-Sheng Lai, Ling Xie,Department of Pathology, the Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing 210029, Jiangsu Province, China
Hei-Ying Jin,National Center of Colorectal Surgery, the Third Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing 210001, Jiangsu Province, China
Supported byNational Natural Science Foundation of China, No. 30572447
Correspondence to:Hei-Ying Jin, National Center of Colorectal Surgery, the Third Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing 210001, Jiangsu Province, China. jinheiying@yahoo.com.cn
Received:2006-12-15 Accepted:2007-02-08
Abstract
AIM: To analyze the relationship between microsatellite instability (MSI) and clinicopatho-logical features in sporadic colorectal cancer and its clinical significance.
METHODS: Fluorescence multiplex polymerase chain reaction was used to detect the microsatellite instability with five microsatellite loci in 105 patients with sporadic colorectal cancer. The clinicopathological features characterized by microsatellite instability and microsatellite stability were compared statistically.
RESULTS: We found microsatellite instability in 24 ......
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