与乙型肝炎病毒感染相关的易感或拮抗基因的研究进展
遗传基因;乙型肝炎病毒;研究进展,崔建军,田国保,田地,曾争,陆海英,通讯作者:,AdvanceingeneticfactorsinfluencinghepatitisBvirusinfection,Jian-JunCui,Guo-Ba
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崔建军, 田国保, 田地, 北京大学第一医院感染疾病科病毒研究室 北京市 100034
曾争, 陆海英, 北京大学第一医院感染疾病科 北京市 100034
国家自然科学基金资助项目, No. 30671855
美国国家癌症研究所(NCI)资助项目, N01-CO-12400
通讯作者: 曾争, 100034, 北京市, 北京大学第一医院感染疾病科. zeng@bjmu.edu.cn
电话: 010-66551799 传真: 010-66551799
收稿日期: 2007-01-21 接受日期: 2007-03-06
Advance in genetic factors influencing hepatitis B virus infection
Jian-Jun Cui, Zheng Zeng, Guo-Bao Tian, Di Tian, Hai-Ying Lu
Jian-Jun Cui, Guo-Bao Tian, Di Tian,Laboratory of Virology, Department of Infectious Diseases, the First Hospital of Peking University, Beijing 100034, China
Zheng Zeng, Hai-Ying Lu,Department of Infectious Diseases, the First Hospital of Peking University, Beijing 100034, China
Supported byNational Natural Science Foundation of China, No. 30671855, and the Fund from the National Cancer Institute of United States, N01-CO-12400
Correspondence to:Zheng Zeng, Department of Infectious Diseases, the First Hospital of Peking University, Beijing 100034, China. zeng@bjmu.edu.cn
Received: 2007-01-21 Accepted:2007-03-06
Abstract
Hepatitis B virus (HBV) infection is a major global health problem. A complex combination of environment and virus, especially host genetic factors, play a critical role in determining both susceptibility to HBV persistence and different clinical outcomes after HBV infection. In this review, we summarized the main relevant genes such as human leukocyte antigen (HLA), tumor necrosis factor (TNF), interleukins (ILs), interferons (IFNs), etc. However, in order to identify all the relevant polymorphisms that affect the outcome of HBV infection, alternative strategies such as genome-wide association studies with large sample sizes are required to define the majority of the related genes.
Key Words: Genetic factors; Hepatitis B virus; Advance
Cui JJ, Zeng Z, Tian GB, Tian D, Lu HY. Advance in genetic factors influencing hepatitis B virus infection ......
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