胃癌Runx3基因的甲基化
胃癌;Runx3基因;甲基化,杨少辉,戴冬秋,通讯作者:,MethylationstatusofRunx3geneinhumangastriccancer,Shao-HuiYang,Dong-QiuDai,Supportedby,Correspondenc
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杨少辉, 戴冬秋, 中国医科大学附属第一医院肿瘤外科 辽宁省沈阳市 110001
国家自然科学基金资助项目, No. 30271477, 30572162
教育部留学回国人员科研启动基金项目, No. 2002-247
教育部“高等学校博士学科点专项科研基金”资助项目, No. 20050159001
通讯作者: 戴冬秋, 110001, 辽宁省沈阳市, 中国医科大学附属第一医院肿瘤外科. daidq63@163.com
电话: 024-83283560
收稿日期: 2006-10-27 接受日期: 2007-02-08
Methylation status of Runx3 gene in human gastric cancer
Shao-Hui Yang, Dong-Qiu Dai
Shao-Hui Yang, Dong-Qiu Dai,Department of Oncological Surgery, the First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China
Supported byNational Natural Science Foundation of China, No. 30271477, No. 30572162; the Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry, No. 2002-247; and the Special Scientific Research Foundation for High School Doctor Subject, State Education Ministry, No. 20050159001
Correspondence to:Dr. Dong-Qiu Dai, Department of Oncological Surgery, the First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China. daidq63@163.com
Received:2006-10-27 Accepted:2007-02-08
Abstract
AIM: To investigate the relationship between the methylation status of Runx3 gene and human primary gastric cancer.
METHODS: The methylation status of Runx3 gene in 38 gastric carcinoma specimens, the corresponding normal gastric mucosa and lymph nodes was detected by methylation-specific polymerase chain reaction (MS-PCR).
RESULTS: Aberrant methylation of Runx3 gene was detected in 73.7% of gastric cancer specimens, 65.8% of lymph nodes and 21.1% of the corresponding normal mucosa, and there were significant differences between the former two and the latter. Runx3 methylation was significantly correlated with the tumor size (P = 0.021), but not with the general types, differentiation degree, invasion depth and growth style of gastric cancer ......
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