肝富集转录因子对乙型肝炎病毒转录与复制的调控
乙肝病毒;转录与复制;肝富集转录因子,王甦,唐红,通讯作者:,RegulationofhepatitisBvirustranscriptionandreplicationbyliver-enrichedtranscriptionalfactor
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王甦, 四川大学华西医院感染性疾病中心, 生物治疗国家重点实验室感染性疾病分子生物学研究室(现在扬州大学医学院附院感染科) 四川省成都市 610041
唐红, 四川大学华西医院感染性疾病中心 四川省成都市 610041
国家杰出青年基金资助项目, No. 30325036
通讯作者: 唐红, 610041, 四川省成都市国学巷37号, 四川大学华西医院感染性疾病中心. htang6198@hotmail.com
收稿日期: 2007-01-13 接受日期: 2007-02-12
Regulation of hepatitis B virus transcription and replication by liver-enriched transcriptional factors
Su Wang, Hong Tang
Su Wang,Center of Infectious Diseases, West China Hospital of Sichuan University; Molecular Biology Division of Infectious Diseases, National Key Laboratory of Biotherapy, Sichuan University, Chengdu 610041, Sichuan Province, China
Hong Tang,Center of Infectious Diseases, West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province, China
Supported bythe National Science Fund for Distinguished Young Scholars, No. 30325036
Correspondence to:Hong Tang, Center of Infectious Diseases, West China Hospital of Sichuan University, 610041, Sichuan Province, China. htang6198@hotmail.com
Received: 2007-01-13 Accepted:2007-02-12
Abstract
Hepatotropism is a prominent feature of hepatitis B virus (HBV). Cell lines of nonhepatic origin do not independently support HBV replication. In this review, we show that the nuclear hormone receptors, hepatocyte nuclear factor 4 and retinoid X receptor plus peroxisome proliferator-activated receptor, support HBV replication in nonhepatic cells by controlling pregenomic RNA synthesis, indicating that these liver-enriched transcription factors control a unique molecular switch restricting viral tropism. In contrast, hepatocyte nuclear factor 3 antagonizes nuclear hormone receptor-mediated viral replication, demonstrating distinct regulatory roles for these liver-enriched transcription factors.
Key Words: Hepatitis B virus; Transcription and replication; Liver-enriched transcription factors
Wang S, Tang H ......
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