肝脏功能重建的细胞来源
肝细胞;干细胞;细胞分化,张瑞,郭善禹,通讯作者:,Cellsourceofliverfunctionalreconstruction,RuiZhang,Shan-YuGuo,Supportedby,Correspondenceto:,Received:,A
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张瑞, 郭善禹, 上海交通大学附属第九人民医院普外科 上海市 200011
上海市第九人民医院2004科学研究基金项目
通讯作者: 郭善禹, 200011, 上海市制造局路639号, 第九人民医院普外科. guoshyu@hotmail.com
电话: 021-63138341
收稿日期: 2007-01-23 接受日期: 2007-02-13
Cell source of liver functional reconstruction
Rui Zhang, Shan-Yu Guo
Rui Zhang, Shan-Yu Guo,Department of General Surgery, the Ninth People’s Hospital of Shanghai Jiao Tong University, Shanghai 200011, China
Supported bythe Scientific Research Foundation of the Ninth People’s Hospital Shanghai Municipality during the Year 2004
Correspondence to:Shan-Yu Guo, Department of General Surgery, the Ninth People’s Hospital of Shanghai Jiao Tong University, Shanghai 200011, China. guoshyu@sina.com
Received:2007-01-23 Accepted:2007-02-13
Abstract
Recent years, various new techniques, such as bioartificial liver system, hepatocyte transplantation and tissue engineering, were being employed to fight against the liver diseases. However, the shortage of liver cells has become a prominent problem. This review focuses on the current research progress of the liver cell differentiation source, and it also discusses the advantages and disadvantages of various hepatic stem cells and nonhepatic stem cells, expecting to provide a reference for liver cell source selection during tissue engineering, an adequate and suitable source for bioartificial liver and hepatocyte transplantation and to help to treat liver diseases.
Key Words: Hepatocyte; Stem cell; Cell differentiation
Zhang R, Guo SY. Cell source of liver functional reconstruction. Shijie Huaren Xiaohua Zazhi 2007;15(11):1261-1265
摘要
生物人工肝、肝细胞移植、组织工程等技术的开展, 为肝病的治疗开辟了新的途径. 然而, 肝细胞来源短缺已经逐渐成为一个突出的问题. 本文着重论述了目前肝脏细胞的分化来源研究进展情况, 并对各种肝源性和非肝源性干细胞的优缺点进行了讨论, 以期为肝组织工程选择细胞来源提供参考, 为生物人工肝、肝细胞移植提供充足、合适的细胞来源, 协助治疗肝脏疾病.
关键词: 肝细胞; 干细胞; 细胞分化
张瑞, 郭善禹. 肝脏功能重建的细胞来源. 世界华人消化杂志 2007;15(11):1261-1265 ......
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