Survivin、P16及RB表达与原发性胆囊癌发生和发展的关系
胆囊肿瘤;Survivin;P16;RB基因,许元鸿,欧阳兵,于国志,郭克建,许元鸿,通讯作者:,CorrelationsofSurvivin,P16andRetinoblastomaexpressionwiththeoccu
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许元鸿, 欧阳兵, 于国志, 郭克建, 中国医科大学附属第一医院普通外科 辽宁省沈阳市 110001
许元鸿, 医学博士, 副教授, 副主任医师, 主要从事胆道胰腺肿瘤的诊断和治疗.
通讯作者: 许元鸿, 110001, 辽宁省沈阳市, 中国医科大学附属第一医院普通外科. yuanhongxu@hotmail.com
电话: 024-83283330
收稿日期: 2007-03-18 接受日期: 2007-04-13
Correlations of Survivin, P16 and Retinoblastoma expression with the occurrence and progression of primary gallbladder carcinoma
Yuan-Hong Xu, Bing Ou-Yang, Guo-Zhi Yu, Ke-Jian Guo
Yuan-Hong Xu, Bing Ou-Yang, Guo-Zhi Yu, Ke-Jian Guo,Department of General Surgery, the First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China
Correspondence to: Xu Yuan-Hong,Department of General Surgery, the First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China. yuanhongxu@hotmail.com
Received:2007-03-18 Accepted:2007-04-13
Abstract
AIM: To investigate the roles of Survivin, P16 and Retinoblastoma (RB) protein expression in the occurrence and progression of primary gallbladder carcinoma (PGC).
METHODS: Immunohistochemistry was used to detect the expression of Survivin, P16 and RB in 46 cases of PGC tissues, 22 cases of cancer-adjacent tissues and 19 cases of benign lesions.
RESULTS: The positive rates of Survivin, P16 and RB expression in PGC tissues were 69.6% (32/46), 47.8% (22/46) and 71.7% (33/46), respectively, significantly different from those in the benign (0%, 73.7%, 94.7%) and cancer-adjacent (0%, 95.4%, 95.4%) tissues (P < 0.05 or P < 0.01). P16 expression was negatively correlated with Survivin and RB expression (r = -0.691, P < 0.01; r = -0.6556, P < 0.01). The positive rate of Survivin expression in P16/RB-deleted cases was 93.8%, significantly higher than that in P16/RB-positive ones (χ2 = 9.228, P < 0.01). Survivin expression was also correlated closely with the differentiation degree (P = 0 ......
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