NF-κB与细胞凋亡
NF-κB;细胞凋亡;信号转导通路,苏剑东,吴灵飞,通讯作者:,Relationshipbetweennuclearfactor-kappaBandcellapoptosis,Jian-DongSu,Ling-FeiWu,Correspondenceto:Ling-
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苏剑东, 吴灵飞, 汕头大学医学院第二附属医院消化内科 广东省汕头市 515041
通讯作者: 吴灵飞, 515041, 广东省汕头市东厦北路, 汕头大学医学院第二附属医院消化内科. lingfeiwu@21cn.com
电话: 0754-8915810 传真: 0754-8346543
收稿日期: 2007-01-16 接受日期: 2007-03-28
Relationship between nuclear factor-kappa B and cell apoptosis
Jian-Dong Su, Ling-Fei Wu
Jian-Dong Su, Ling-Fei Wu,Department of Gastroenterology, the Second Affiliated Hospital of Shantou University Medical College, Shantou 515041, Guangdong Province, China
Correspondence to: Ling-Fei Wu,Department of Gastroenterology, the Second Affiliated Hospital of Shantou University Medical College, Dongxia North Road, Shantou 515041, Guangdong Province, China. lingfeiwu@21cn.com
Received:2007-01-16 Accepted:2007-03-28
Abstract
The roles of nuclear factor-kappa B (NF-κB) fa-mily and its signaling transduction pathway in apoptosis has been the focus of intense investigation all over the world. Researches show that NF-κB signaling pathway exerts anti-apoptotic function via many other proteins, including IAPs, Bcl-2, TRAF, JNK, FLIP, A20, Gadd45b, MnSOD and so on, but the exact mechanism remains unclear. Inhibition of NF-κB activation can promote the process of programmed cell death, and may become new avenues for therapeutic intervention in immune diseases, chronic inflammatory diseases and certain cancers. Furthermore, recent studies reveal that NF-κB can promote apoptosis, and the types and quantity of NF-κB subunits play a key role in apoptosis. In this review, we presented an overview of the progress in the relationship between NF-κB and apoptosis.
Key Words: Nuclear factor-kappa B; Cell apoptosis; Signaling transduction pathway
Su JD, Wu LF. Relationship between nuclear factor-kappa B and cell apoptosis. Shijie Huaren Xiaohua Zazhi 2007;15(12):1411-1416
摘要
NF-κB家族及其介导的细胞信号转导通路在细胞凋亡中的作用是国内外研究的热点. 研究发现, NF-κB信号转导途径可以通过多种途径抑制细胞凋亡, 与IAPs家族、Bcl-2家族、TRAF家族、JNK、FLIP、A20、Gadd45b、MnSOD等有很大关系, 但其具体机制尚未完全清楚 ......
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