炎症性肠病与肠道细菌研究进展
炎症性肠病;肠道细菌;溃疡性结肠炎;克罗恩病,张静,韩英,王继恒,通讯作者:,Advanceontherelationshipbetweeninflammatoryboweldiseaseandintestinalbacteria,JingZhang,Y
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张静, 中国人民解放军总医院军医进修学院 北京市 100853
韩英, 王继恒, 北京军区总医院消化内科 北京市 100700
通讯作者: 张静, 100853, 北京市, 中国人民解放军总医院军医进修学院. xinzhongdeyu@163.com
收稿日期: 2007-02-26 接受日期: 2007-03-31
Advance on the relationship between inflammatory bowel disease and intestinal bacteria
Jing Zhang, Ying Han, Ji-Heng Wang
Jing Zhang,Chinese PLA Postgraduate Medical School, General Hospital of Chinese PLA, Beijing 100853, China
Ying Han, Ji-Heng Wang,Department of Gastroenterology, General Hospital of Beijing Military Command, Beijing 100700, China
Correspondence to:Jing Zhang, Chinese PLA Postgraduate Medical School, General Hospital of Chinese PLA, Beijing 100853, China. xinzhongdeyu@163.com
Received:2007-02-26 Accepted:2007-03-31
Abstract
The pathogenesis of inflammatory bowel disease, including ulcerative colitis and Crohn′s disease, is still not entirely understood today. The possible etiology includes host genetic susceptibility, mucosal immunity and intestinal microecology as well as their interactions. With the development of mircoecology in recent years, there were increasing interests in the correlation between intestinal bacteria and pathogenesis of IBD. Many studies reported the pathogenesis of enteropathogenic microorganism and a series of immunological, microecological and pathophysiological changes in IBD. At the same time, many animal experiments and clinical applications have proved the predominance of microecological preparation on intestinal tract immunoloregulation, controlling of inflammatory reaction and so on. Probiotics which is one of the microecological preparation has been generally used. This article reviewed the advances on the relationship between inflammatory bowel disease and intestinal bacteria and the use of probiotics in the treatment of IBD.
Key Words: Inflammatory bowel disease; Intestinal bacterium; Ulcerative colitis; Crohn′s disease ......
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