人食管癌组织中β1-整合素mRNA的表达及其意义
食管癌;β1-整合素;逆转录-聚合酶链式反应,人食管癌组织中β1-整合素mRNA的表达及其意义,张军,张文君,郭家龙,林意,原野,通讯作者:,Expressionandsignificanceofβ1-integrinmRNAinhumanesophagealcancer,JunZhang
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张军, 张文君, 郭家龙, 林意, 原野, 郧阳医学院附属太和医院胸心外科 湖北省十堰市 442000
通讯作者: 张文君, 442000, 湖北省十堰市, 郧阳医学院附属太和医院超声科. pulushi68@126.com
电话: 0719-8801336
收稿日期: 2007-01-15 接受日期: 2007-01-31
Expression and significance of β1-integrin mRNA in human esophageal cancer
Jun Zhang, Wen-Jun Zhang, Jia-Long Guo, Yi Lin, Ye Yuan
Jun Zhang, Wen-Jun Zhang, Jia-Long Guo, Yi Lin, Ye Yuan,Department of Thoracic and Cardiovascular Surgery, the Affiliated Taihe Hospital of YunYang Medical College, Shiyan 442000, Hubei Province, China
Correspondence to:Wen-Jun Zhang, Department of ultrasonography, the Affiliated Taihe Hospital of YunYang Medical College, Shiyan 442000, Hubei Province, China. pulushi68@126.com
Received:2007-01-15 Accepted:2007-01-31
Abstract
AIM: To ingestigate the expression of β1-integrin in human esophageal carcinoma and its correlation with clinical pathology.
METHODS: The expression of β1-integrin mRNA was detected in 30 cases of esophageal carcinoma and cancer-adjacent tissues by reverse transcriptase polymerase chain reaction (RT-PCR).
RESULTS: The expression of β1-integrin mRNA in esophageal carcinoma tissues was significantly higher than that in the normal esophageal tissues (1.205 ± 0.379 vs 0.470 ± 0.166, P = 0.003), and it was also markedly higher in the cases with metastasis than that in the ones without metastasis (1 ......
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