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编号:11495650
胡颓子多糖对小肠辐射损伤的保护作用
http://www.100md.com 2007年5月8日 廖泽云, 林 平, 李玉山, 姜锦林
胡颓子多糖;小肠辐射损伤;二胺氧化酶;氧自由基;细胞因子,廖泽云,林平,李玉山,姜锦林,通讯作者:,EffectsofElaeagnusbockiiDielspolysaccharideonthesmallintestineofmiceafterwhole
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     廖泽云, 林平, 李玉山, 湖北民族学院医学院 湖北省恩施市445000

    姜锦林,
湖北民族学院附属医院中医儿科教研室 湖北省恩施市 445000

    湖北省卫生厅科研基金项目, No. JX2C42

    通讯作者:
廖泽云, 445000, 湖北省恩施市学院路39号, 湖北民族学院医学院. lzy121192004@126.com

    电话: 0718-8431861

    收稿日期: 2007-01-25 接受日期: 2007-02-09

    Effects of Elaeagnus bockii Diels polysaccharide on the small intestine of mice after whole body irradiation with 60Cog ray

    
Ze-Yun Liao, Ping Lin, Yu-Shan Li, Jin-Ling Jiang

    Ze-Yun Liao, Ping Lin, Yu-Shan Li,
Medical School of Hubei Institute for Nationalities, Enshi 445000, Hubei Province, China

    Jin-Ling Jiang,
Department of Traditional Chinese Medicine (Paediatrics), the Affiliated Hospital of Medical School of Hubei Institute for Nationalities, Enshi 445000, Hubei Province, China

    Correspondence to:
Ze-Yun Liao, Medical School of Hubei Institute for Nationalities, 39 Xueyuan Road, Enshi 445000, Hubei Province, China. lzy121192004@126.com

    Received:
2007-01-25 Accepted:2007-02-09

    Abstract

    AIM: To study the protective effect of Elaeagnus bockii Diels (EbD) polysaccharide on the small intestine of mice after whole body irradiation with 60Coγ ray.

    METHODS: Sixty Kunming mice were divided in normal group, irradiative injury group, and EbD-treated groups (100, 300, 500 mg/kg). Irradiative injury was induced using 60Coγ ray. EbD polysaccharide was administered by clyster once a day for two weeks. Fourteen days later, the mice were sacrificed and about 2-cm segment of duodenum, jejunum and ileum were dissected respectively for crypt survival assay. The contents of intestinal mucosal protein, DNA and diamine oxidase (DAO) were determined. The activity of superoxide dismutase (SOD), the level of malondialdehyde (MDA) in the small intestine, the serum levels of tumor necrosis factor (TNF), interleukin-4 (IL-4) and IL-6 were also measured ......

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