甘露醇对大鼠小肠移植缺血再灌注损伤的保护作用
小肠移植;缺血再灌注;甘露醇;氧自由基;大鼠,赵正维,王为忠,管文贤,于小迪,通讯作者:,Protectiveeffectsofmannitolagainstsmallbowelischemiaandreperfusioninjuryaftertra
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赵正维, 王为忠, 管文贤, 于小迪, 第四军医大学西京医院胃肠外科 陕西省西安市 710033
国家自然科学基金资助项目, No. 30371400
通讯作者: 管文贤, 710033, 陕西省西安市, 第四军医大学西京医院胃肠外科. guanwenxian@medmail.com.cn
电话: 029-84775261
收稿日期: 2007-01-18 接受日期: 2007-02-08
Protective effects of mannitol against small bowel ischemia and reperfusion injury after transplantation in rats
Zheng-Wei Zhao, Wei-Zhong Wang, Wen-Xian Guan, Xiao-Di Yu
Zheng-Wei Zhao, Wei-Zhong Wang, Wen-Xian Guan, Xiao-Di Yu,Department of Gastrointestinal Surgery, Xijing Hospital of the Fourth Military Medical University, Xi’an 710033, Shaanxi Province, China
Supported byNational Natural Science Foundation of China, No. 30371400
Correspondence to:Guan Wen-Xian, Department of Gastrointestinal Surgery, Xijing Hospital of the Fourth Military Medical University, Xi’an 710033, Shaanxi Province, China. guanwenxian@medmail.com.cn
Received:2007-01-18 Accepted:2007-02-08
Abstract
AIM: To investigate the effect of mannitol on small bowel ischemia and reperfusion (I/R) injury after transplantation and its possible mechanism.
METHODS: Rat models of small bowel I/R injury after transplantation were established in male rats. All the rats were randomly divided into sham operation group, I/R group and mannitol-treated group. After 0.5, 1 and 1.5 hours of I/R, intestinal tissues were collected for histopathological examination. The content of malondialdehyde (MDA) and activity of superoxide dismutase (SOD) in the intestinal tissues.
RESULTS: The height and thickness of intestinal intestinal villi were significantly lower in I/R group than those in sham operation group (P < 0.01) and mannitol-treated group (P < 0.05). At different time points, the content of MDA was markedly higher in I/R group (16.24 ± 4.56, 18.50 ± 2.89, 19.42 ± 2.21) than that in sham operation group (10.26 ± 1.72, P < 0.01) and mannitol-treated group (11 ......
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