辅助性T细胞的研究概况及进展
辅助性T细胞;乙型肝炎病毒;免疫,王辉,游晶,通讯作者:,CurrentstatusandadvanceonThelpercells,HuiWang,JingYou,Correspondenceto:,Received:,Accepted:,Abstra
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王辉, 游晶, 昆明医学院第一附属医院感染病科 云南省昆明市 650032
通讯作者: 游晶, 650032, 云南省昆明市西昌路295号, 昆明医学院第一附属医院感染病科. jingyoukm@126.com
电话: 0871-5324888
收稿日期: 2006-11-10 接受日期: 2006-12-08
Current status and advance on T helper cells
Hui Wang, Jing You
Hui Wang, Jing You,Department of Infectious Diseases, the First Affiliated Hospital of Kunmin Medical College, Kunming 650032, Yunnan Province, China
Correspondence to:Jing You, Department of Infectious Diseases, the First Hospital of Kunmin Medical College, 295 Xichang Road, Kunming 650032, Yunnan Province, China. jingyoukm@126.com
Received:2006-11-10 Accepted:2006-12-08
Abstract
T helper cells play an important role in the immune modulation of human bodies. According to the different cytokines secreted by them, T helper cells can be divided into two subgroups, named Th1 and Th2, and they participate in the modulation of cell-mediated and humoral immune response respectively. Th1 and Th2 can affect immune patterns in bodies by co-adjustment. Coming from the common precursor cells (Th0), Th1 and Th2 can commutate under the influence of different cytokines and antigens. In normal physiological condition, the immune function of Th1/Th2 is in dynamic balance. Once the balance is broken, organisms will be in morbid state.
Key Words: T helper cell; Hepatitis B virus; Immunization
Wang H, You J. Current status and advance on T helper cells. Shijie Huaren Xiaohua Zazhi 2007;15(13):1532-1536
摘要
CD4+ Th细胞是机体重要的免疫调节细胞, 根据其产生细胞因子的不同分为Th1和Th2亚型, 分别参与调节细胞免疫和体液免疫. Th1和Th2可相互调节, 影响免疫应答的格局. 他们来自共同的前体细胞Th0, 在不同的细胞因子、抗原等因素的影响下, 可发生Thl与Th2的转换. 在生理条件下, 机体Th1/Th2细胞的免疫功能处于动态平衡, 一旦这种平衡发生偏离, 机体就会趋向疾病状态.
关键词: 辅助性T细胞; 乙型肝炎病毒; 免疫
王辉, 游晶. 辅助性T细胞的研究概况及进展. 世界华人消化杂志 2007;15(13):1532-1536
0 引言
辅助性T细胞(helper T cell, Th)对机体的特异性和非特异性免疫均具有重要调节作用, 能协助B细胞产生抗体, 也能促进其他T细胞的分化成熟, 是机体内一类重要的免疫调节细胞 ......
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