第三代头孢菌素引发消化道出血的机制分析
第三代头孢菌素;黏膜损害;大出血,张建辉,赵保民,通讯作者:,Analysisonthemechanismofgastrointestinalhemorrhagecausedbythethird-generationcephalosporins,J
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张建辉, 中国人民武装警察部队陕西省消防总队医院外科 陕西省西安市 710016
赵保民, 中国人民解放军第四军医大学唐都医院消化科 陕西省西安市 710038
通讯作者: 张建辉, 710016, 陕西省西安市凤城二路15号, 中国人民武装警察部队陕西省消防总队医院外科. zlt_1994@sina.com
电话: 029-86167620
收稿日期: 2007-02-08 接受日期: 2007-04-03
Analysis on the mechanism of gastrointestinal hemorrhage caused by the third-generation cephalosporins
Jian-Hui Zhang, Bao-Min Zhao
Jian-Hui Zhang,Department of Surgery, Shaanxi General Fire Brigade Hospital of Chinese PLA Armed Force, Xi’an 710016, Shaanxi Province, China
Bao-Min Zhao,Department of Digestive Diseases, Tangdu Hospital Affiliated to the Fourth Military Medical University, Xi’an 710016, Shaanxi Province, China
Correspondence to:Jian-Hui Zhang, Department of Surgery, Shaanxi General Fire Brigade Hospital of Chinese PLA Armed Force, 15 Fengcheng Second Road, Xi’an 710016, Shaanxi Province, China. zlt_1994@sina.com
Received:2007-02-08 Accepted:2007-04-03
Abstract
AIM: To probe into the possible mechanism of gastrointestinal hemorrhage induced by the third generation of cephalosporins.
METHODS: The related literatures in the past 30 years were collected and retrospective analyzed.
RESULTS: The third generation of cephalosporins caused mucosal injury of various organs, such as gastrointestinal tract, respiratory tract or urinary tract, complicated with hemorrhage. Besides, the injuries also occurred in heart, lung, and nerve. Adverse reactions were found in 73 cases, of which 6 were confirmed with gastrointestinal mucosal injury, 2 with urinary mucosal injury, and 1 with respiratory mucosal injury, and the 9 cases were all complicated with hemorrhage ......
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