胃癌癌变过程中Smad4表达的变化及其与临床病理特征的关系
胃癌;肠上皮化生;不典型增生;Smad4;免疫组织化学,徐岩,王振宁,徐惠绵,陈亚男,罗阳,徐岩,通讯作者:,ChangeofSmad4expressioningastriccarcinogenesisanditsclinico
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徐岩, 王振宁, 徐惠绵, 中国医科大学附属第一医院肿瘤外科 辽宁省沈阳市 110001
陈亚男, 罗阳, 中国医科大学医学基因组学教研室, 卫生部细胞生物学重点实验室 辽宁省沈阳市 110001
徐岩, 2002年中国医科大学本科毕业, 现博士在读, 主要从事胃癌的分子生物学和临床研究.
国家杰出青年科学基金资助项目, No. 30125017
国家自然科学基金资助项目, No. 30370640
通讯作者: 徐惠绵, 110001, 辽宁省沈阳市和平区北二马路92号, 中国医科大学附属第一医院肿瘤外科. xuhuimian@126.com
电话: 024-83283555
收稿日期: 2007-01-14 接受日期: 2007-03-07
Change of Smad4 expression in gastric carcinogenesis and its clinicopathological significance
Yan Xu, Ya-Nan Chen, Zhen-Ning Wang, Yang Luo, Hui-Mian Xu
Yan Xu, Zhen-Ning Wang, Hui-Mian Xu,Department of Surgical Oncology, the First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China
Ya-Nan Chen, Yang Luo,the Key Laboratory of Cell Biology of Health Ministry; Research Center for Medical Genomics, China Medical University, Shenyang 110001, Liaoning Province, China
Supported bythe National Science Foundation for Distinguished Young Scholars, No. 30125017, and National Natural Science Foundation of China, No. 30370640
Correspondence to:Hui-Mian Xu, Department of Surgical Oncology, the First Affiliated Hospital of China Medical University, 92 Beier Road, Shenyang 110001, Liaoning Province, China. xuhuimian@126.com
Received:2007-01-14 Accepted:2007-03-07
Abstract
AIM: To characterize the changes of Smad4 expression in the multistage carcinogenesis of gastric cancer and investigate the correlations between these changes and the clinicopatholo-gical features.
METHODS: The expression of Smad4 was detected by immunohistochemisty in the paraffin-embedded samples from 103 patients with gastric carcinoma (16 cases in early stage, 87 cases in progressive stage). The result was comparatively analyzed with the histopathology.
RESULTS: Among 103 gastric carcinoma samples, 28 cases with intestinal metaplasia and 13 cases with atypical hyperplasia were determined ......
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