人原发性直肠恶性淋巴瘤裸小鼠原位移植模型的建立及其生物学特性
直肠肿瘤;恶性淋巴瘤;肿瘤移植;肿瘤转移;疾病模型,魏强,刘秋珍,脱朝伟,张宁,杨波,朱希伟,王明耀,魏强,通讯作者:,Establishmentoforthotopictransplantationmodelofhuma
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魏强, 中国疾病预防控制中心 北京市 100052
刘秋珍, 脱朝伟, 张宁, 杨波, 中国人民解放军第202医院普通肝胆外科 辽宁省沈阳市 110003
朱希伟, 王明耀, 辽宁省肿瘤医院 辽宁省沈阳市 110042
魏强, 助理研究员, 博士, 主要从事病毒学及基因治疗研究, 目前从事病原微生物实验室生物安全研究与管理工作.
“九五”国家重点医学科技攻关计划资助项目, No. 96A230603
辽宁省自然科学基金项目, No. 20042153
通讯作者: 脱朝伟, 110003, 辽宁省沈阳市, 中国人民解放军第202医院普通肝胆外科. lqztcw@sina.com
收稿日期: 2007-01-30 接受日期: 2007-02-13
Establishment of orthotopic transplantation model of human primary rectal lymphoma in nude mice and investigation of its biologic characteristics
Qiang Wei, Qiu-Zhen Liu, Chao-Wei Tuo, Ning Zang, Bo Yang, Xi-Wei Zhu, Ming-Yao Wang
Qiang Wei,Chinese Center for Disease Control and Prevention, Beijing 100052, China
Qiu-Zhen Liu, Chao-Wei Tuo, Ning Zang, Bo Yang,Department of Hepatobiliary Surgery, the 202nd Hospital of Chinese PLA, Shenyang 110003, Liaoning Province, China
Xi-Wei Zhu, Ming-Yao Wang,Shenyang Cancer Hospital, Shenyang 110042, Liaoning Province, China
Supported bythe Ninth Five-Year Plan Research Foundation for the Key Medical Research Project, No. 96A230603, and the Natural Science Foundation of Liaoning Province, No. 20042153
Correspondence to:Chao-Wei Tuo, Department of Hepatobiliary Surgery, the 202nd Hospital of Chinese PLA, Shenyang 110003, China. lqztcw@sina.com
Received:2007-01-30 Accepted:2007-02-13
Abstract
AIM: To establish an orthotopic transplantation model of human primary rectal lymphoma in nude mice and investigate its biologic features.
METHODS: Histologically fresh lymphoma tissues from a case of primary rectal lymphoma during operation were transplanted into rectal mucosa of nude mice. Tumorgenecity, invasion, metastasis, morphology (light microscopy, electron microscopy and immunohistochemistry), karyotype analysis and DNA content of orthotopically transplanted tumors were studied.
RESULTS: According to the new WHO classification of malignant lymphoma, an orthotopic transplantation model of human primary rectal lymphoma (non-Hodgkin’s, B cell, high malignancy) in nude mice (HRBL-0305) was successfully established ......
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