牛磺酸对大鼠幽门结扎型胃溃疡的影响
大鼠;胃溃疡;幽门;牛磺酸;胃酸;胃蛋白酶;ATP酶,余良主,王帮华,黄碧兰,唐琼,丁洁琼,通讯作者:,Effectoftaurineongastriculcerinpylorus-ligatedrats,Liang-ZhuYu,Bang-HuaWang
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余良主, 王帮华, 黄碧兰, 唐琼, 丁洁琼, 湖北省咸宁学院医学院生理教研室 湖北省咸宁市 437100
通讯作者: 余良主, 437100, 湖北省咸宁市, 咸宁学院医学院生理教研室. yuliangyu73@163.com
电话: 0715-8161471
收稿日期: 2006-12-25 接受日期: 2007-01-20
Effect of taurine on gastric ulcer in pylorus-ligated rats
Liang-Zhu Yu, Bang-Hua Wang, Bi-Lan Huang, Qiong Tang, Jie-Qiong Ding
Liang-Zhu Yu, Bang-Hua Wang, Bi-Lan Huang, Qiong Tang, Jie-Qiong Ding,Department of Physiology, Medical School of Xianning College, Xianning 437100, Hubei Province, China
Correspondence to:Liang-Zhu Yu, Department of Physiology, Medical school of Xianning College, Xianning 437100, Hubei Province, China. yuliangyu73@163.com
Received:2006-12-25 Accepted:2007-01-20
Abstract
AIM: To explore the effect of taurine on the pylorus ligation-induced gastric ulcer in rats and its mechanism.
METHODS: Rat model of gastric ulcer was made by pylorus ligation method. A total of 45 Wistar rats were randomly and averagely divided into 3 groups: normal control group, ulcer model group and taurine-treated group. Six hours later, all the rats were killed, and the gastric mucosal ulcer index (UI), total acidity of gastric juice, pepsin activity and H+,K+-ATPase activity in parietal cells were measured.
RESULTS: In comparison with the normal control group, the ulcer model group showed an increase in UI (35.3 ± 3.7 vs 0, P < 0.01), total acidity of gastric juice (28.56 ± 3.81 mmol/L vs 20.34 ± 4.40 mmol/L, P < 0.01), pepsin activity (7.58 ±1.58 μg/(mL·min)vs 5.83 ± 1.22 μg/(mL·min), P < 0.01) and H+, K+-ATPase activity of parietal cells (8.86 ± 1.50 U/mg vs 6.95 ± 1.03 U/mg,P < 0.01). However, in the treated group, the gastric mucosal injury was attenuated, and the value of gastric mucosal UI (15.4 ± 3.6vs 35.3 ± 3.7, P < 0.01), total acidity of gastric juice (19.58 ± 3.68 mmol/L vs 28.56 ± 3.81 mmol/L, P < 0.01), pepsin activity [6.36 ± 1 ......
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