应用蛋白质组学技术筛选胰腺癌生物标志物的研究进展
蛋白质组学;胰腺癌;双向凝胶电泳;质谱;电喷雾电离;基质辅助激光解析电离,刘辉,张海婧,陈国强,吕丽艳,李智立,通讯作者:,Researchprogressinscreeningbiomarkersofpancreaticcancerbyprote
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刘辉, 张海婧, 陈国强, 吕丽艳, 李智立, 中国医学科学院中国协和医科大学基础医学研究所 北京市 100005
北京市自然科学基金资助项目, No. 7062042
通讯作者: 李智立, 100005, 北京市, 中国医学科学院中国协和医科大学基础医学研究所. lizhili@ibms.pumc.edu.cn
电话: 010-65296475
收稿日期: 2007-01-29 接受日期: 2007-04-03
Research progress in screening biomarkers of pancreatic cancer by proteomic techniques
Hui Liu, Hai-Jing Zhang, Guo-Qiang Chen, Li-Yan Lv, Zhi-Li Li
Hui Liu, Hai-Jing Zhang, Guo-Qiang Chen, Li-Yan Lv, Zhi-Li Li, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China
Supported by Natural Science Foundation of China, No. 7062042
Correspondence to: Zhi-Li Li, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China. lizhili@ibms.pumc.edu.cn
Received: 2007-01-29 Accepted: 2007-04-03
Abstract
Pancreatic cancer is one kind of devastating diseases. Those patients without nonspecific symptoms at early stage had mostly lost the opporunity of surgical therapy when pancreatic cancer was detected at advanced stage. Rapid growth of proteomic technologies provides possibilities to study etiopathogenesis, and screen early diagnostic and prognosis biomarkers of pancreatic cancer. In this paper, the application of proteomic techniques in cell lines, tissues, serum and pancreatic juice from patients with pancreatic cancer is reviewed briefly.
Key Words: Proteomics; Pancreatic cancer; Two-dimensional polyacrylamide gel electrophoresis; Mass spectrometry; Electrospray ionization; Matrix-assisted laser desorption/ionization
Liu H, Zhang HJ, Chen GQ, Lv LY, Li ZL. Research progress in screening biomarkers of pancreatic cancer by proteomic techniques. Shijie Huaren Xiaohua Zazhi 2007;15(14):1628-1633
摘要
胰腺癌是一种十分凶险的恶性肿瘤. 胰腺癌早期症状不明显, 临床确诊的患者多已处于中晚期, 大多失去手术治疗机会. 蛋白质组技术的快速发展为研究胰腺癌发病机制、发现早期诊断和预后的生物标志物提供了可能 ......
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