NERD患者埃索美拉唑联合莫沙必利与加强生活方式干预对照研究112例
非糜烂性胃食管反流病;埃索美拉唑;莫沙必利;生活方式干预,季代金,黄茂涛,余宁,赵悦,陈勇,通讯作者:,Efficacyofesomeprazole,mosaprideandlifestyleenhancementinthetr
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季代金, 黄茂涛, 余宁, 赵悦, 陈勇, 中国人民解放军第452医院消化内科 四川省成都市 610021
通讯作者: 季代金, 610021, 四川省成都市, 中国人民解放军第452医院消化内科. jidaijin@163.com
电话: 028-85399452-97313
收稿日期: 2007-01-15 接受日期: 2007-03-06
Efficacy of esomeprazole, mosapride and lifestyle enhancement in the treatment of non-erosive gastroesophageal reflux disease: an analysis of 58 cases and comparative study
Dai-Jin Ji, Mao-Tao Huang, Ning Yu, Yue Zhao, Yong Chen
Dai-Jin Ji, Mao-Tao Huang, Ning Yu, Yue Zhao, Yong Chen, Department of Digestive Diseases, the 452nd Hospital of Chinese PLA, Chengdu 610021, Sichuan Province, China.
Correspondence to: Dai-Jin Ji, Department of Digestive Diseases, the 452nd Hospital of Chinese PLA, Chengdu 610021, Sichuan Province, China. jidaijin@163.com
Received: 2007-01-15 Accepted: 2007-03-06
Abstract
AIM: To investigate the therapeutic effects of lifestyle enhancement on patients with non-erosive gastroesophageal reflux disease (NERD) based on the combined treatment of esomeprazole and mosapride.
METHODS: A total of 112 NERD patients were divided into control group (n = 54) and test group (n = 58). All the patients were given esomeprazole (40 mg, qd) and mosapride (5 mg, tid) for 8 weeks. Besides, the lifestyle in test group was enhanced (adjusting lifestyle, diet, mental status and movement intensity). Chi-square test was conducted to compare the efficacy between the two groups.
RESULTS: In the test group, notable efficacy was found in 42 cases, effectivity in 12 cases, and inefficacy in 4 cases and the total effective rate was 93.10% (54/58). In the control group, notable efficacy was observed in 26 cases, effectivity in 18 cases, and inefficacy in 10 cases are ineffective, and the total effective rate was 81.84% (44/54). There was significant difference between the two groups (χ2 = 7.39, P < 0.01).
CONCLUSION: On the basis of treatment by esomeprazole and mosapride, lifestyle enhancement can improve the compliance and clinical symptoms of NERD patients ......
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