CHFR基因与消化道肿瘤关系的研究进展
有丝分裂前期;细胞周期检查点;CHFR基因;消化道肿瘤,高余佳,辛彦,通讯作者:,Advanceintherelationshipbetweencheckpointwithforkheadassociatedandringfingergeneandca
 |
| 第1页 |
参见附件(825KB，5页)。
高余佳, 中国医科大学博士, 辽宁省肿瘤医院内六科 辽宁省沈阳市 110042
辛彦, 中国医科大学附属第一医院肿瘤研究所第四研究室 辽宁省沈阳市 110001
国家自然科学基金资助项目, No. 30371607
教育部博士点专项基金资助项目, No. 20040159021
通讯作者: 辛彦, 110001, 辽宁省沈阳市和平区南京北街155号, 中国医科大学附属第一医院肿瘤研究所第四研究室. yxin@mail.cum.edu.cn
电话: 024-83282351
收稿日期: 2007-04-01 接受日期: 2007-04-13
Advance in the relationship between checkpoint with fork head associated and ring finger gene and carcinomas of digestive tract
Yu-Jia Gao, Yan Xin
Yu-Jia Gao,Doctor from China Medical University, the Sixth Department of Internal Medicine, Cancer Hospital of Liaoning Province, Shenyang 110042, Liaoning Province, China
Yan Xin,the Fourth Laboratory of Cancer Institute, the First Affiliated Hospital of China Medical University, Shengyang 110001, Liaoning Province, China
Supported byNational Natural Science Foundation of China, No. 30371607, and the Specialized Research Fund for the Doctoral Program of Education Ministry, No. 20040159021
Correspondence to:Professor Yan Xin, the Fourth Laboratory of Cancer Institute, the First Affiliated Hospital, China Medical University, 155 Nanjing North Street, Heping District, Shengyang 110001, Liaoning Province, China. yxin@mail.cum.edu.cn
Received:2007-04-01 Accepted:2007-04-13
Abstract
CHFR (checkpoint with fork head associated and ring finger), a novel checkpoint gene, was frequently inactivated in human cancers. In response to mitotic stress, it causes a delay in chromosome condensation during prophase. Studies have showed that the direct target of the CHFR pathway was Plk1. In vitro-translated Plk1 is ubiquitinated, in a CHFR-dependent manner, both in Xenopus interphase extracts as well as in a purified system reconstituted with recombinant proteins. In addition, by excluding Cyclin B1 from the nucleus, regulating Aurora-A level and acting with the P38 stress kinases, CHFR blocks entry to mitosis prophase in mammalian cells ......
您现在查看是摘要介绍页，详见PDF附件(825KB，5页)。