遗传性非息肉病性大肠癌中hMSH2, hMLH1, TβRⅡ, MMP-7及TIMP-2的表达和其特殊生物学行为间的关系
遗传性非息肉病性大肠癌;散发性大肠癌;错配修复基因;转化生长因子βⅡ型受体;基质金属蛋白酶-7;基质金属蛋白酶组织抑制因子-2;免疫组织化学,遗传性非息肉病性大肠癌中hMSH2,hMLH1,TβRⅡ,MMP-7及TIMP-2的表达和其特殊生物学行为间的关系,顾国利,魏学明,王石林,任力,胡益云
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顾国利, 魏学明, 王石林, 中国人民解放军空军总医院普通外科 北京市 100036
任力, 胡益云, 李德昌, 中国人民解放军空军总医院病理科 北京市 100036
顾国利, 硕士, 主治医师, 主要从事胃肠道临床肿瘤学的研究.
通讯作者: 王石林, 100036, 北京市, 中国人民解放军空军总医院普通外科. wangshilin@medmail.com.cn
电话: 010-66928302
收稿日期: 2007-02-10 接受日期: 2007-03-19
Expression of hMSH2, hMLH1, transforming growth factor β receptor type Ⅱ, matrix metalloproteinase-7, tissue inhibitor of metalloproteinase-2 and their correlations with the biological behaviors of hereditary nonpolyposis colorectal cancer
Guo-Li Gu, Xue-Ming Wei, Shi-Lin Wang, Li Ren, Yi-Yun Hu, De-Chang Li
Guo-Li Gu, Xue-Ming Wei, Shi-Lin Wang,Department of General Surgery, General Hospital of Chinese PLA Air force, Beijing 100036, China
Li Ren, Yi-Yun Hu, De-Chang Li,Department of Pathology, General Hospital of Chinese PLA Air force, Beijing 100036, China
Correspondence to:Shi-Lin Wang, Department of General Surgery, General Hospital of Chinese PLA Air force, Beijing 100036, China. wangshilin@medmail.com.cn
Received:2007-02-10 Accepted:2007-03-19
Abstract
AIM: To investigate the correlation of hMSH2, hMLH1, transforming growth factor β receptor type Ⅱ (TβRⅡ), matrix metalloproteinase-7 (MMP-7) and tissue inhibitor of metalloprotei-nase-2 (TIMP-2) expression with the biological behaviours of human hereditary nonpolyposis colorectal cancer (HNPCC).
METHODS: Immunohistochemical staining was used to detect the expression of hMSH2, hMLH1, TβRⅡ, MMP-7 and TIMP-2 protein in 30 cases of sporadic colorectal cancer (SCRC), 30 cases of HNPCC and 8 cases of normal colorectal mucosa, and their corresponding clinical datas were studied retrospectively.
RESULTS: The positive rates of hMSH2, hMLH1, TβRⅡ, MMP-7 and TIMP-2 expression were significantly related to the depth of invasion and lymph node metastasis, but not to the sex of patients and the size or position of tumors ......
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